BIAS OF RELATIVE RISK ESTIMATES OBTAINED FROM AFFECTED SIB PAIR LINKAGE DATA

遗传流行病学统计分析 计算机程序包为研究人员提供了必要的工具 用于人类家庭的各种类型的统计遗传分析 数据。在资助这一资源之前，很少有这样的计算机 程序是可用的，而现有的程序通常很差 记录在案，不易从一种类型的计算机移植到 又一个。这个子项目已经通过开发 用于基因分析的计算机程序，这些程序有很好的文档和 可在不同的计算机和操作系统之间移植。S.A.G.E. 3.0版于1997年3月发布。此版本是用来编写的 ANSI标准C，并包含RELPAL和TDTEX的测试版，其中 现已敲定。RELPAL是一个要筛选的通用程序 数量性状与标记的遗传连锁 相对配对关系。TDTEX执行各种精确的 传动不平衡测试。图形用户界面(图形用户界面) 为用户提供了在 用户友好的环境。它是基于Web的通用访问。这个 测试版图形用户界面于1997年5月发布。一部功能齐全的作品 Windows和Unix的版本现已在3.1版中提供。

The S.A.G.E. (Statistical Analysis for Genetic Epidemiology) computer program package provides researchers with the tools necessary for various types of statistical genetic analysis of human family data. Prior to the funding of this resource, few such computer programs were available, and those in existence were usually poorly documented and not easily transportable from one type of computer to another. This subproject has addressed these problems by developing computer programs for genetic analysis that are well documented and portable between different computers and operating systems. S.A.G.E. version 3.0 was released in March, 1997. This version was written in ANSI standard C and contained beta releases of RELPAL and TDTEX, which have now been finalized. RELPAL is a general program to screen for genetic linkage of quantitative traits to markers on the basis of relative pair relationships. TDTEX performs a variety of exact transmission disequilibrium tests. A GUI (graphical user interface) provides users the ability to specify analysis parameters in a user-friendly environment. It is Web based for universal access. The beta GUI was released in May, 1997. A fully functional production release for both Windows and Unix is now available in version 3.1.