A novel G-Protein Coupled Receptor-based memory process mediating the cognitive control of action.

在许多神经退行性疾病和精神疾病中，可以观察到认知控制行动的缺陷。我们已经发现了纹状体中一种新的神经元机制的证据，该机制介导了与认知控制相关的关键记忆过程，我们将通过操纵纹状体及其在杏仁核和中线丘脑的传入来探索这一过程，如果成功，我们将为目前被忽视的疾病的治疗提供新的靶点。

Deficits in the cognitive control of action are observed in a number of neurodegenerative and psychiatric conditions. We have found evidence of a novel neuronal mechanism in the striatum that mediates a key memory process associated with cognitive control that we will explore using manipulations of the striatum and of its afferents in the amygdala and midline thalamus and that, if successful, we provide novel targets for treatment of what is currently a much neglected condition.