CELL RESPONSE TO HIGHLY ORDERED PROTEIN MONOLAYERS: MULTIVARIATE STATISTICS

链霉亲和素-生物素系统正被用作模型系统 调查高度有序的表面单层是否可以缓解 生物材料表面的非特异性细胞反应，以及 特定的细胞反应可以通过结合适当的 多肽信号进入这样的表面。目前，ESCA和SIMS正在 用于表征吸附在表面的链霉亲和素 生物素终止的自组装单分子膜。最终链霉亲和素 具有特定肽序列的衍生品将用于 研究这些多肽是否可以控制细胞反应 序列被曝光。混合派生种群稍后将 调查过了。将使用内皮细胞和平滑肌细胞 以确定细胞对表面的反应。

The streptavidin-biotin system is being used as a model system to investigate whether highly ordered surface monolayers can mitigate non-specific cell response to biomaterial surfaces, and whether specific cell responses can be engineered by incorporating appropriate peptide signals into such a surface. At present, ESCA and SIMS are being used to characterize streptavidin adsorbed onto biotin-terminated self-assembled monolayers. Eventually streptavidin derivatives having specific peptide sequences will be employed to study whether cell response can be controlled when these peptide sequences are exposed. Mixed derivative populations will later be investigated. Endothelial cells and smooth muscle cells will be used to determine cell response to the surfaces.