COMPUTATIONAL STUDY OF HORMONE BINDING DETERMINANTS IN HGHBP COMPLEX

丙氨酸扫描是一种成熟的实验策略， 确定蛋白质之间的特定侧链相互作用。 然而，这种策略是劳动力和时间消耗。 我们正在开发 一种计算策略来确定特定的侧链 人生长激素与受体相互作用 这一战略 只需运行一次分子动力学模拟，并免费 能源分析如下。 我们看到了受体-受体复合物， 尤其是结合位点。 交互式计算机图形学 资源对于检查我们的模拟结果非常有用。

Alanine scanning is a well established experimental strategy to identify the specific side chain interaction between proteins. However, this strategy is labor and time consuming. We are developing a computational strategy to determine the specific side chain interaction between human growth hormone and receptor. This strategy requires only a single run of molecular dynamic simulations with free energy analysis following. We visualize the hormone-receptor complex, especially the binding site. The interactive computer graphics resources are very useful for examining our simulation results.