OPTICAL PROPERTIES OF BIO TISSUES W/ STUDY USING FREQ DOMAIN PHOTON MIGRATION

激光微束和医疗计划(LAMMP)设施提供 访问多频频域光子迁移(FDPM) 已经证明其能够提取光学属性的系统， 散射和吸收，从单距离测量到 人体组织上的组织状幻影和活体。我们，在EPFL(Dr。 Depeursinge的团队)，已经开发出一种空间分辨光子 允许本地光学特性的迁移(SRPM)探头 生物组织的测量。我们目前的数据分析 程序基于测量结果与以下结果的比较 蒙特卡罗数值模拟。我们建议联合进行 使用LAMMPFDPM装置的实验研究和临床应用 资源，以定义最佳的光子迁移系统 精确推导复杂的、非均匀的光学性质 纸巾。这项研究涉及1)定量测定 每种技术中询问的组织体积；2)实验 组织状层状固体体模的研究 能够通过使用以下工具分别对每一层进行光学表征 我们的组合设置；3)最佳系统的设计(Probe+ 反转模型)根据对势能的彻底分析 短距离调频的优势(&lt；J5J mm)；4) 乳房、脑和妇科人体组织的临床试验 活着。我们相信LAMP能够为我们提供一套独特的 最适合完成的实验和临床设施 我们在这一领域研究的长期目标，即体内光学 组织定性作为诊断和成像的辅助手段。这个 这项研究的结果和我们使用LAMMPFDPM的经验 仪器将有助于我们在光子迁移方面的研究工作 以及我们在欧盟赞助的项目中的贡献 生物医学--近红外光谱和成像(NIRSI)。

Laser Microbeam and Medical Program (LAMMP) facilities provide access to a multi-frequency, Frequency-Domain Photon Migration (FDPM) system which has proven its ability to extract optical properties, scattering and absorption, from a single-distance measurement on tissue-like phantoms and in vivo on human tissues. We, at EPFL (Dr. Depeursinge's group), have developed a Spatially-Resolved Photon Migration (SRPM) probe which allows local optical property measurements of biological tissues. Our current data analysis procedure is based upon comparisons of measurements to results of Monte Carlo numerical simulations. We propose to conduct combined experimental studies, using the LAMMP FDPM apparatus and clinical resources, to define an optimal photon migration system capable of deriving accurately the optical properties of complex, inhomogeneous tissues. This study involves 1) a quantitative determination of the volume of tissue interrogated in each technique; 2) an experi mental study on tissue-like layered solid phantoms in order to assess our ability to optically characterize each layer independently by using our combined setup; 3) the design of an optimal system (probe + inversion model) according to a thorough analysis of the potential advantages of frequency modulation at short distances (<J5Jmm); 4) clinical trials on breast, brain and gynecological human tissues, in vivo. We believe that LAMMP is able to provide us with a unique set of experimental and clinical facilities, which is optimal to complete the long-term goal of our research in this field, i.e. in vivo optical characterization of tissues as an aid to diagnostics and imaging. The outcome of this study and our experience in using LAMMP FDPM instrumentation will benefit our research efforts in photon migration and our contribution in the European Union-sponsored program Biomed-Near InfraRed Spectroscopy and Imaging (NIRSI).