EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGING

描述(改编自申请者摘要)：心血管(C-V) 系统是受衰老过程影响最大的器官系统之一。 C-V发病率和死亡率因种族和性别而有显著差异 这会影响寿命。这项拟议的研究涉及一项混血儿 (黑白)人群中C-V风险因素和 博加卢萨心脏研究过去25年的生活方式。具体目标 研究的重点是描述特征(内在衰老与风险因素 负担)对亚临床C-V的影响 正常衰老过程中的疾病过程。自那以来收集的大量数据库 童年提供了与无症状的潜在C-V疾病相关的信息 衰老。这项研究队列包括1200名出生于1959年至1969年之间的人， 从孩提时代起，他们至少接受了四次检查。这批人将是 检查：1)C-V风险因素变量，包括肥胖测量、血液 压力、血脂、脂蛋白、载脂蛋白、同型半胱氨酸、葡萄糖、 胰岛素、纤维蛋白原、纤溶酶原激活物抑制物1、细胞间黏附 分子-1，C反应蛋白、过氧化脂质和微量白蛋白尿；2) 生活方式和心理社会变量，如烟酒使用、身体状况 活动、饮食和生活改变事件；3)心脏的亚临床变化和 通过回声-多普勒测量观察血管系统(结果变量) 心脏-颈动脉结构和功能与臂、桡动脉 顺应性；以及4)选择与长寿相关的等位基因标记，如apoE。 这些变量(等位基因标记除外)将在两个点上进行测量 时间上，每隔3年。此外，长寿家族史和 研究对象及其父母和祖父母的健康史信息 将获得评估队列的家族性风险特征。这个 拟议的研究将提供对正常衰老和 影响亚临床C-V病病程的易感因素 黑人和白人人口步入中年。理解C-V的演变 正常衰老的风险可以导致更合理的成功衰老计划 和长寿和预防C-V疾病。

DESCRIPTION (Adapted from the Applicant's Abstract): The cardiovascular (C-V) system is one of the organ systems most affected by the aging process. Significant differences in C-V morbidity and mortality occur by race and gender that influence longevity. The proposed research involves a biracial (black-white) population that has been followed for C-V risk factors and lifestyles in the Bogalusa Heart Study over the past 25 years. The specific aim of the research is to characterize traits (intrinsic aging vs. The risk factor burden) in a population reaching middle age that influence the subclinical C-V disease process in normal aging. The extensive data base collected since childhood provides information related to silent underlying C-V disease and aging. The study cohort includes 1,200 individuals born between 1959 and 1969, who were examined at least four times since childhood. The cohort will be examined for: 1) C-V risk factor variables comprising obesity measures, blood pressure, lipids, lipoproteins, apoliproproteins, homocysteine, glucose, insulin, fibrinogen, plasminogen activator inhibitor 1, intercellular adhesion molecules -1, C-reactive protein, lipid peroxides and microalbuminuria; 2) lifestyle and psychosocial variables such as tobacco and alcohol use, physical activity, diet, and life change events; 3) subclinical changes of the heart and vasculature (outcome variables) observed by echo-Doppler measurements of cardiac-carotid structure and function and brachial and radial artery compliance; and 4) selected longevity-associated allele markers, like apoE. These variables (except for the allele markers) will be measured at two points in time, with a 3-year interval. In addition, a family history of longevity and health history information on study subjects and their parents and grandparents will be obtained to evaluate familial risk characteristics of the cohort. The proposed studies will provide insights into the interaction of normal aging and predisposing factors that influence the subclinical C-V disease process in a black-white population reaching middle age. Understanding the evolution of C-V risk in normal aging can lead to more rational programs for successful aging and longevity and C-V disease prevention.