SURVIVAL AND AGE AT DIAGNOSIS OF BREAST CANCER

描述：（改编自研究者摘要） 乳腺癌的治疗效果和诊断时的年龄之间的关系 长期以来，疾病一直存在争议。的效果进行评估 年龄和其他个体特征对诊断为 乳腺癌，我们建议用一个扩展的武器库来解决这个问题， 生存分析的现代统计方法。在此过程中，我们将使用数据 通过SEER计划确定的乳腺癌患者。的 在这项基于人群的研究中，最重要的考虑因素是估计 不同类别女性患者的风险函数和治愈率 特别强调各年龄层的差异。预后意义 将使用回归分析研究检测乳腺癌时的年龄 非参数平滑技术和参数过程的对应物 用于估计危险函数。这些方法提供了一种方法， 解释年龄和其他协变量的影响， 影响肿瘤治愈的概率（存活分数）或 故障发生的时间。这样的解释提供了更深层次的 深入了解决定目前实践的临床结果的因素 治疗方法

DESCRIPTION: (Adapted from the Investigator's Abstract) The relationship between the efficacy of treatment for breast cancer and age at diagnosis of the disease has long been and still remains controversial. To assess the effect of age and other individual characteristics on survival of women diagnosed with breast cancer we propose to attack the problem with an extended arsenal of modern statistical methods of survival analysis. In doing so, we will use data on patients with breast cancer identified through the SEER Program. The foremost consideration in this population-based study will be estimation of the hazard function and cure rates for different categories of female patients with special emphasis on variations across age strata. The prognostic significance of age at detection of breast cancer will be studied using regression counterparts of nonparametric smoothing techniques and parametric procedures designed for estimation of the hazard function. These methods offer a way to interpret the effect of age and other covariates in terms of their predominant influence either on the probability of tumor cure (surviving fraction) or on the timing of failure occurrence. Such an interpretation provides a deeper insight into factors determining clinical outcome of currently practiced treatment methods.