VASCULAR STIFFNESS AND EFFECTS OF DIETARY INTERVENTION

描述：（改编自研究者摘要）血管硬化可以 被视为衡量“生物老化”的血管，并可能是一个 随后动脉粥样硬化和/或高血压的早期指示。 的 在人群中进行血管硬度的研究需要准确和 可重复的措施。 目前还没有衡量的金标准 血管僵硬的流行病学研究。 研究人员建议， 评估三种不同的技术脉搏波速度超声波 压力脉动信号的成像和分析， 再现性和与亚临床颈动脉粥样硬化的关系。 将在各种人群中评价血管硬度， 一系列潜在的风险因素将被探索。 共1250例受试者 将被研究。 首先，他们将获得血管硬度测量结果， 在他们的科室接受颈动脉超声检查的人群， 目前已有大量风险因素数据。 其中包括300 围绝经期妇女300例，绝经后妇女300例，中年妇女200例（40 - 70 非裔美国人和高加索人。 此外，他们还将招募200名 年轻人（20 - 40岁），非裔美国人和高加索人。 他们的 初步资料提示同型半胱氨酸可能与血管紧张素Ⅱ相关， 硬度，这将在非洲裔美国人和 白人受试者 最后，还将添加其他营养成分。 通过对250名受试者进行血管硬度测量进行了探索， INTERMAP研究的匹兹堡队列。 这将使调查人员 评估血管僵硬度和详细营养状况之间的关系， 以最先进的方式收集的数据。 总之， 研究人员指出，这项研究将提供一个全面的概述， 血管硬度测量与年龄、性别、种族、绝经 状态，激素使用，颈动脉粥样硬化，超声心动图测量， 危险因素（包括血压、体重、体脂分布、身体 肥胖，脂质，饮食，钠和钾排泄，血管反应性， 社会心理变量），以及亚临床和临床心血管 疾病 他们进一步指出，在一个实验室进行研究， 通过仔细的、可重复的测量， 血管僵硬，这可能是一个重要组成部分， 动脉粥样硬化和高血压风险。

DESCRIPTION: (Adapted from Investigator's Abstract) Vascular stiffening can be viewed as a measure of the "biologic aging" of the vessels and may be an early indication of subsequent atherosclerosis and/or hypertension. The study of vascular stiffness in human populations requires accurate and reproducible measures. There is currently no gold standard for measurement of vascular stiffness in epidemiological studies. The investigators propose to evaluate three different techniques, pulse wave velocity, ultrasound imaging and analysis of the pressure pulsation signal, with respect to their reproducibility and relationship to subclinical carotid atherosclerosis. Vascular stiffness will be evaluated in a variety of populations and a wide range of potential risk factors will be explored. A total of 1250 subjects will be studied. First, they will obtain vascular stiffness measures in populations undergoing carotid ultrasound in their department for whom a wealth of risk factor data are already available. These include 300 perimenopausal women, 300 postmenopausal women, and 200 middle-aged (40 - 70 years) African Americans and Caucasians. In addition, they will recruit 200 young adults (20 - 40 years), African American and Caucasian. Their preliminary data suggest that homocysteine may related to vascular stiffness, and this will be carefully evaluated in African American and Caucasian subjects. Finally, additional nutritional factors will be explored by performing vascular stiffness measures on 250 subjects from the Pittsburgh cohort of the INTERMAP study. This will allow the investigators to evaluate associations between vascular stiffness and detailed nutritional data that have been collected in a state-of-the-art manner. In summary, the investigators state that this study will provide a comprehensive overview of vascular stiffness measures in relationship to age, sex, race, menopausal status, hormone use, carotid atherosclerosis, echocardiographic measures, risk factors (including blood pressure, weight, body fat distribution, body fatness, lipids, diet, sodium and potassium excretion, vascular reactivity, psychosocial variables), and subclinical and clinical cardiovascular disease. They further state that conducting the study in one laboratory with careful, reproducible measures will allow a thorough evaluation of vascular stiffness, which is likely to be an important component of atherosclerosis and hypertension risk.