ORTHOTOPIC LIVER TRANSPLANTATION

这个应用是为了研究移植的机制。 耐受性，特别是肝脏。校长 推动这些研究的假设如果首席调查员的那么- 被称为“双向范式”。这表明， 同种异体移植代表着两种免疫学的结合 力量：典型的宿主对移植物的攻击，即同种异体移植排斥反应，以及 嫁接VS宿主。后者是一种神秘的免疫力量在起作用。 尽管肝脏移植物抗宿主病的临床实体 移植是不常见的，它本质上代表着一种严肃的努力。 移植物中包含的白细胞在移植后排斥受者 迁移。因此，调查人员的建议是，接受者 变得充满了来自供体器官的少量细胞 这种“移植物对宿主”反应的结果是促进了 宽容。当这些细胞离开移植物时，它们被替换在 受者免疫细胞移植成功的病例。在这 假说，宿主与移植物疾病如果不受控制是不好的，因为它 导致同种异体移植物的排斥反应。反过来说，贪污与房主 疾病如不加控制可致人于死地，但若加以控制则可降温。 拒绝。提出的研究将检验这一假设。此外， 调查人员将尝试开发新的技术来修改 供体细胞的数量和特征最终驻留在 并促进对同种异体移植物的耐受性。

This application is designed to study the mechanisms of transplantation tolerance with particular reference to the liver. The principal hypothesis driving these studies if the Principal Investigator's so- called "Two-Way Paradigm". This proposes that the ultimate outcome of allograft transplantation represents the composite of two immunologic forces: classic host vs. graft attack, i.e. allograft rejection, and graft vs. host. The latter is an occult immunologic force at work. Although the clinical entity of graft vs. host disease in liver transplantation is uncommon, it represents in essence a serious effort by leukocytes contained in the graft to reject the recipient after their migration. Thus, it is the investigator's proposal that the recipient becomes populated with small numbers of cells from the donor organ and that the effect of this "graft vs. host" reaction is the promotion of tolerance. As these cells leave the graft, they are replaced in the transplant by immune cells of the recipient in successful cases. In this hypothesis, host vs. graft disease if uncontrolled is bad because it leads to rejection of the allograft. The other way round, graft vs. host disease if unchecked can kill the patient, but if controlled it tempers rejection. The studies proposed will test this hypothesis. Moreover, the investigators will attempt to develop novel techniques to modify the number and character of the donor cells that ultimately reside in the recipient and promote tolerance to the allograft.