GENOMICS OF POTASSIUM CHANNELS IN C ELEGANS

描述：这是一项进行全面研究的建议， 将揭示其结构、表达模式和基本功能 C.所有钾通道的特性。优雅 该项目将 在一只动物中提供对整个K通道集的第一次一瞥， 有利于任何细胞，组织类型或丰度类，揭示方面， 如果没有完整的基因， 序列的 最初，C. elegans 华盛顿大学的基因组项目将被编译，然后 将确定单个K通道的表达模式。 因为 在一个有机体中估计有100个钾通道， 神经元，这些通道中的许多可能是协调调节， 表达式;这可能是复杂的电行为所需要的。 这 研究可能导致不仅是结构和功能性质的概况， 而且还包括组织分布和表达的量和时间。 这些 数据可以用作解释人类基因组序列数据的模型， 并且还可以导致临床应用。

DESCRIPTION: This is a proposal to undertake a comprehensive study that will reveal the structure, expression patterns, and basic functional properties of all potassium channels in C. elegans. The project will provide the first glimpse of the entire K channel set in one animal, without favoring any cell, tissue type or abundance class, revealing aspects of genomic organization that are not discernible without the complete gene sequences. Initially, all sequence information revealed by the C. elegans genomic project at Washington University will be compiled, and then the expression patterns of individual K channels will be determined. Because there are an estimated 100 potassium channels in an organism with only 302 neurons, many of these channels may be under coordinated regulation for expression; this may be required for complex electrical behavior. This study may lead to a profile not only of structure an functional properties, but also tissue distribution and amount and timing of expression. These data may serve as a model for interpreting the human genome sequence data, and may also lead to clinical applications.