IN-VIVO MR MICROSCOPY INSTRUMENTATION AT 11.7 TESLA

我们需要一台11.7特斯拉磁共振(MR)仪器，配备89毫米垂直口径超导螺线管。这台仪器将使我们能够在小鼠和小鼠身上进行高分辨率的在体磁共振显微实验。我们已经召集了来自卡内基梅隆大学和匹兹堡大学的8名NIH资助的研究人员(即5名主要用户和3名次要用户)，他们的研究项目将从这种高场磁共振显微镜仪器的可获得性中受益匪浅。这8个用户的研究领域涵盖生物医学科学的广泛领域，例如脑结构和功能、器官移植、脑肿瘤、头部创伤、心脏病学、神经学和基底膜。这些研究人员在他们的研究项目中使用了各种小鼠和大鼠模型。拟议的磁共振仪器将安置在匹兹堡核磁共振中心，该中心由卡内基梅隆大学和匹兹堡大学建立，是一个研究和培训设施，利用动物模型，特别是大鼠和小鼠，将磁共振成像(MRI)和光谱分析(MRS)应用于生物医学科学。核磁共振中心拥有操作和维护拟议仪器的基础设施和人员。我们要求从共享仪器计划获得500,000美元，作为拟议仪器的部分成本。卡内基梅隆大学已同意支付11.7特斯拉磁共振仪器的费用余额，超过50万美元，并支付翻新核磁共振中心毗邻房间以容纳拟议仪器所需的费用。

We are requesting an 11.7-Tesla magnetic resonance (MR) instrument equipped with an 89-mm vertical bore superconducting solenoid. This instrument will allow us to carry out high-resolution in-vivo MR microscopic experiments on mice and small rats. We have assembled eight NIH-funded investigators from both Carnegie Mellon University and the University of Pittsburgh (i.e., five major and three minor users) whose research projects will greatly benefit from the availability of this high-field MR microscopic instrument. The research areas of these eight users cover a broad spectrum in biomedical sciences, e.g., brain structure and function, organ transplantation, brain tumors, head trauma, cardiology, neurology, and basement membrane. These investigators use various mouse and rat models in their research projects. The proposed MR instrument will be housed in the Pittsburgh NMR Center which was established by Carnegie Mellon University and the University of Pittsburgh as a research and training facility for applications of magnetic resonance imaging (MRI) and spectroscopy (MRS) using animal models, in particular rats and mice, to biomedical sciences. The NMR Center has the infrastructure and personnel to operate and maintain the proposed instrument. We are requesting $500,000 from the Shared Instrumentation Program as the partial cost for the proposed instrument. Carnegie Mellon University has agreed to pay the balance of the cost for an 11.7-Tesla MR instrument in excess of $500,000 and to pay the expenses needed for renovating a room located contiguous to the NMR Center to house the proposed instrument.