BRUKER AVANCE 4.7T NMR SPECTROMETER UPGRADE

阿拉巴马大学伯明翰分校的4.7T/40cm核磁共振光谱仪是13年前安装的。它在核磁共振研究与开发中心发挥着独特的作用，弥合了布鲁克宽径360 MHz核磁共振光谱仪（89毫米直径孔）和布鲁克AVANCE 4.1T全身核磁共振光谱仪（1m孔）之间的差距。相对高场（4.7T）宽口径（40厘米）设计使其成为鬼怪和动物核磁共振成像和光谱实验的理想平台，以及4.1 T全身系统实施前的开发工作。自安装以来的十年见证了现有NMR技术的革命，这使得现有的控制台和支持硬件过时了。由于它的年龄，可靠性和维修问题现在威胁到现有系统所拥有的少数能力。我们诚挚地请求资金将现有的4.7T磁铁升级到当前最先进的系统，该系统将为该机构目前正在进行的nih资助的一些项目提供高速成像，增强光谱定位和扩散能力。我们目前的4.7T核磁共振系统不具有屏蔽梯度，这是减少快速成像序列产生的涡流所必需的。随着屏蔽梯度的增加，噪声和伪影的减少也提高了空间和时间分辨率，更高的梯度值和更快的切换时间允许实现处于核磁共振研究和开发前沿的序列。我们也在申请新主机的资金，以利用我们将从新梯度中看到的好处。通过使用更快的处理器和更大的编程灵活性，我们将能够实现序列，这将为那些目前使用4.7T系统的项目提供不可估量的好处，以回答他们的研究问题，并帮助设计未来提案的新策略。

The 4.7T/40cm NMR spectrometer at the University of Alabama at Birmingham was installed thirteen years ago. It serves an unique role in the Center for NMR Research and Development, bridging the gap between the Bruker wide-bore 360 MHz NMR spectrometer (89 mm dia bore), and the Bruker AVANCE 4.1T whole body NMR spectrometer (1m bore). The relatively high field (4.7T) wide-bore (40 cm) design makes it an ideal platform for both NMR imaging and spectroscopy experiments on phantoms and animals, and developmental work prior to implementation on the 4.1 T whole body system. The intervening decade since its installation has seen a revolution in existing NMR technology, which has rendered the existing console and supporting hardware obsolete. Due to its age, reliability and repair issues are now threatening to curtail what few capabilities the existing system does possess. We respectfully request funds to upgrade the existing 4.7T magnet to a current state-of-the-art system, which will provide high speed imaging, enhanced spectroscopic localization, and diffusion capabilities to a number of NIH-funded projects currently underway at this institution. Our current 4.7T NMR system does not possess shielded gradients, which are necessary for the reduction of eddy currents that are generated by fast imaging sequences. The reduction in noise and artifacts which accompany the addition of shielded gradients also improve both spatial and temporal resolution, and the higher gradient values and faster switching times allow implementation of sequences which are at the cutting edge of NMR research and development. We are also requesting funds for a new console to take advantage of the benefits we will see from the new gradients. Through the use of faster processors and greater programming flexibility, we will be able to implement sequences that will provide immeasurable benefit to those projects that currently use the 4.7T system to answer their research questions, and aid in the design of new strategies for future proposals.