UPGRADE OF A 4.7T/40CM GE OMEGA CSI NMR SPECTROMETER

高磁场是核磁共振优化信噪比和光谱分辨率的必要条件。为此，1986年约翰霍普金斯大学医学院购买了一台4.7T/40cm的通用电气MR仪器，用于多种动物模型的生物医学研究。由于该仪器是此类仪器中最早的型号之一，因此在NCRR共享仪器拨款计划的资助下，它于1991年升级为当时最先进的功能。升级后的欧米茄控制台及其配件表现出色，为约翰霍普金斯及其周围的NMR社区服务了近十年。然而，目前的仪器已经过时，很难维修和保持良好的工作状态。因此，本提案要求对该仪器进行升级，以使其保持在核磁共振技术的前沿。现在的主机已经过时了，并且在图像处方、数据处理和显示以及数据存储方面都非常受限。我们要求用调制解调器BioSpec（Avance）控制台以及Bruker Instruments的新B-GA12主动屏蔽梯度集完全替换现有控制台。这些改进对于约翰霍普金斯医疗机构在肿瘤学、心脏病学、放射学和神经学的各种研究中持续发展空间定位光谱和成像至关重要。

High magnetic fields are essential for optimized signal to noise ratio and spectral resolution in NMR. To this end, a 4.7T/40cm General Electric MR instrument was purchased 1986 by Johns Hopkins University School of Medicine for biomedical research on a variety of animal models. Since this instrument was one of the earliest models in this class of instruments, it was upgraded to then state-of-the-art capabilities in 1991, with funds from the NCRR Shared Instrumentation Grant Program. The upgraded Omega console with its accessories has performed superbly well and served the NMR community in and around Johns Hopkins for nearly ten years now. However, the present instrument has become out-dated and very difficult to service and maintain in good working condition. Consequently this proposal requests an upgrade of this instrument to keep it at the cutting edge of NMR technology. The present console is outdated and very restrictive with regards to graphic prescription, data processing and display, and data storage. We are requesting the complete replacement of the existing console with a modem BioSpec(Avance) console along with a new B-GA12 actively shielded gradient set from Bruker Instruments. These improvements are essential for the continued development of spatially localized spectroscopy and imaging for a variety of studies in oncology, cardiology, radiology and neurology at Johns Hopkins Medical Institutions.