CONCURRENT ETHANOL AND COCAINE WITHDRAWAL--NEUROPSYCHOLOGICAL STUDY

慢性酒精中毒患者的急性戒酒 依赖是已知的沉淀的综合征是可变的， 演示文稿.中枢神经系统与酒精戒断相关 以前已经研究过了。然而，大多数研究都集中在>35 其他药物史有限或未指明的1岁患者 虐待因此，我们对中枢神经系统的影响知之甚少， 由于酒精戒断与其他药物戒断相结合，或 医学（营养不良）或精神病（反社会人格） 经常伴随其他药物滥用的变量。这样的知识 特别是在门诊病人 解毒和未回答的问题，关于这种能力， 患者在家中或工作中安全地执行任务，同时 正在戒酒/戒毒。在这项研究中，我们建议比较 150例饮酒者神经生理和神经心理状况 有（n=75）或无（n=75）共病可卡因的依赖性患者 依赖将对一组非药物依赖性受试者（n=35）进行检测 作为对照。评估组合将包括静息EEG的测量 活动、感觉功能、运动功能、视觉和听觉 选择性注意和短期记忆。述添加剂和/或 维生素缺乏与反社会人格的交互作用 还将评估紊乱。主要假设是， 同时戒除酒精和可卡因依赖的患者 将以EEG特定指标的表现受损为特征 活动，运动和感觉功能。

The acute withdrawal of alcohol from patients with histories of chronic dependence is known to precipitate a syndrome that is variable in its presentation. The central nervous system correlates of alcohol withdrawal have been studied previously. However, most studies have focused on >35 year old patients with limited or unspecified histories of other drug abuse. We therefore have little understanding of the CNS effects that result from combining alcohol withdrawal with other drug withdrawal, or with medical (malnutrition) or psychiatric (antisocial personality) variables that frequently accompany other drug abuse. Such knowledge is particularly relevant in the context of the movement toward outpatient detoxification and unanswered questions regarding the abilities of such patients to safely perform tasks at home or at work while simultaneously undergoing alcohol/drug withdrawal. In this study, we propose to compare the neurophysiological and neuropsychological status of 150 alcohol dependent patients with (n=75) or without (n=75) co-morbid cocaine dependence. A group of non drug-dependent subjects (n=35) will be tested as a control. The assessment battery will include measures of resting EEG activity, sensory functioning, motor functioning, visual and auditory selective attention, and short term memory. The additive and/or interactive effects of vitamin deficiency and antisocial personality disorder will also be evaluated. The principal hypothesis states that patients concurrently withdrawing from both alcohol and cocaine dependence will be characterized by impaired performance on specific measures of EEG activity, and motor and sensory function.