ALCOHOL, HIV INFECTION AND HOST DEFENSE

这是对我们现有的、非常成功的和 生产性酒精研究中心赠款。酒精研究中心 题为“酒精、艾滋病毒感染和宿主防御”的提案是 一群积极的、独立的、原创的人的协调努力 科学家们将他们的智力和体力资源结合在一起 作为地区性和全国性的酒精卓越中心 与酒精有关的研究、培训、教育和 信息传播。我们的研究工作的主要重点是 酒精研究中心成立的第二个五年包括 酒精对SIV(作为HIV模型)感染和继发的影响 感染，酒精和HIV蛋白之间的相互作用，以及 大脑是酒精、艾滋病毒和一氧化氮相互作用的场所。酒精的味道 研究中心拨款建议书由以下部分组成： 行政核心单位、动物核心单位、分子/细胞生物学 实验室核心单元，四个研究组成部分(“酒精，西棉” 免疫缺陷病毒与宿主防御、HIV/SIV与肝脏免疫 酒精系统“，”酒精、HIV-1蛋白和AZT疗法“，”酒精 增强艾滋病神经病变“)和一个试点组件单元。范围很广 为学生和教职员工提供研究培训机会，以及 信息的转移和传播机制也是不可或缺的 酒精研究中心的一部分。除了路易斯安那州立大学医疗中心， 位于卡温顿的区域灵长类中心在 涉及灵长类动物的拟议工作。其中一个研究部分将是 主要在奥克斯纳医学基金会演出。几位教职员工 泽维尔大学的成员和一些学生，主要是以下- 有代表性的少数族裔机构，将参加一些 建议开展的研究和教育活动。

This is a renewal application for our existing, very successful and productive Alcohol Research Center Grant. The Alcohol Research Center proposal entitled "Alcohol, HIV Infection and Host Defense", is a coordinated effort on the part of a group of active, independent, original scientists to combined their intellectual and physical resources into an alcohol center of excellence that serves as a regional and national resource in the field of alcohol-related research, training, education and dissemination of information. The major foci of our research efforts in the second five years of existence of the Alcohol Research Center include the effects of alcohol on SIV (as a model of HIV) infection and secondary infections, the interactions between alcohol and HIV proteins, and the brain as a site of alcohol, HIV, and nitric oxide interaction. The Alcohol Research Center Grant proposal consists of the following parts: Administrative Core Unit, Animal Core Unit, Molecular/Cellular Biology Laboratory Core unit, four Research Components (" Alcohol, Simian Immunodeficiency Virus and Host Defense", HIV/SIV and Hepatic Immune System in Alcoholics", "Alcohol, HIV-1 Proteins and AZT Therapy", "Alcohol Potentiation of AIDS Neuropathy") and a Pilot Component Unit. A wide range of research training opportunities for students and faculty, as well as mechanisms for transfer and dissemination of information re also integral parts of the Alcohol Research Center. In addition to LSU Medical Center, the Regional Primate Center in Covington plays a major role in the proposed work involving primates. One of the research components will be largely performed at the Ochsner Medical Foundation. Several faculty members and some students of Xavier University, a predominantly under- represented minority institution, will be participants in some of the research as well as educational activities that are proposed.