CORE--GENE TARGETED MOUSE FACILITY

这个PPG的中心主题是基因工程小鼠。这个核心是基因靶向小鼠设施，位于洛克菲勒大学。该机构将提供用于每个子项目的基因靶向小鼠。这些小鼠中的大多数已经由Mombaeli博士在洛克菲勒大学的实验室中开发出来。新的菌株将被开发并存放在这个核心。由于在其他机构复制这些小鼠品系的成本很高，而且质量控制必须严格，因此我们选择使用一个单一的设施，通过该设施将小鼠分配给每个组。由于各个实验室地理位置接近，基因靶向小鼠的集中繁殖不会构成障碍。

A central theme in this PPG is the genetically engineered mouse. This Core is the Gene-Targeted Mouse Facility, located at The Rockefeller University. The facility will provide the gene=targeted mice that will be used in each of the subprojects. Most of these mice have already been developed by Dr. Mombaerts in his laboratory at The Rockefeller University. New strains will be developed and deposited in this core. Because duplicating these lines of mice at other institutions is costly and because quality control must be stringent, we have elected to utilize a single facility through which mice will be distribute to each of the groups. Centralized breeding of the gene-targeted mice will not pose a hurdle because of the geographical proximity of the various laboratories.