SEX STEROIDS AND MAMMOGRAM DENSITY IN THE POSTMENOPAUSE

描述：（改编自研究者摘要）流行病学研究 发现乳房X线摄影密度增加是一个独立的风险因素， 乳腺癌和与乳腺X线摄影密度相关的风险程度 比几乎所有其他已知的风险因素都要高， 乳腺癌 这个应用程序集中在3个主要问题：1）是 绝经后妇女内源性类固醇水平与 乳腺摄影密度; 2）用绝经后雌激素治疗， 雌激素/孕激素治疗增加乳腺摄影密度;和3） 雌酮的血清水平是用 绝经后激素治疗可预测乳腺摄影密度变化？ 到 为了解决这些问题， 在绝经后雌激素/孕激素干预（PEPI）试验期间， 使用基于计算机的阈值技术来确定。 PEPI是一个 马结合雌激素的3年随机安慰剂对照试验 (CEE)vs. CEE +3种抗肿瘤药物方案之一，共入组875例 基线时年龄为45-64岁的绝经后女性。 已收集的数据 将在本项目中使用的PEPI将包括： 基线类固醇、PEPI治疗分配、雌酮血清水平 治疗期间和必要的协变量。 该项目将持续3年， 发生在3个地点：加州大学洛杉矶分校，南加州大学，和鲍曼灰色。 具体目标是 1）测量基线时进行的乳房X线照片的密度， 2）确定基线乳腺摄影密度是否与 与内源性类固醇水平; 3）量化之间的关系 乳腺摄影密度和治疗依从性的变化;以及4）确定 密度变化是否与雌酮的血清水平相关 因为激素治疗 通过评估乳房X光片的密度变化 这种基于计算机的方法，以前已经与一个 乳腺癌风险的量化增加，可能会评估 激素的使用能预测多大的风险增加。 的 调查人员说，这可能是一系列 进行调查，以便查明那些风险较高的妇女 绝经后使用补充性激素导致的乳房毒性。

DESCRIPTION: (Adapted from Investigator's Abstract) Epidemiologic studies find that increased mammographic density is an independent risk factor for breast cancer and the magnitude of risk associated with mammographic density is greater than that associated with almost all other known risk factors for breast cancer. This application focuses on 3 major questions: 1) are endogenous levels of sex steroids in postmenopausal women related to mammographic density; 2) does treatment with postmenopausal estrogen and estrogen/progestin therapy increase mammographic density; and 3) do the serum levels of estrone achieved as a result of treatment with postmenopausal hormone therapy predict change in mammographic density? To address these questions, the amount of density of mammograms performed during the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial will be determined using a computer-based threshold technique. PEPI was a 3-year, randomized placebo controlled trial of conjugated equine estrogens (CEE) vs. CEE plus one of 3 progestin regimens, which enrolled 875 postmenopausal women aged 45-64 at baseline. Data already collected as part of PEPI that will be used in this project will include: endogenous sex steroids at baseline, PEPI treatment assignment, estrone serum levels on-treatment, and necessary covariates. The project will last 3 years and take place at 3 sites: UCLA, USC, and Bowman Gray. The specific aims are to: 1) measure the density of mammograms performed at baseline and 12 months; 2) determine whether baseline mammographic density is associated with endogenous levels of sex steroids; 3) quantify the relation between change in mammographic density and adherence to treatments; and 4) determine whether changes density are associated with serum levels of estrone achieved as a result of hormone therapy. By assessing density changes in mammograms with this computer-based method, which has been previously linked to a quantified increase in risk of breast cancer, it may be possible to assess how much of a risk-increase would be predicted by hormone use. The investigators state that this may serve as the first in a series of investigations that would allow identification of those women at higher risk of developing breast toxicity from postmenopausal supplemental hormone use.