EXTRACT OF GINKGO BILOBA (EGB 761) AND VASCULAR FUNCTION

这个应用程序确定一个高度标准化的草药 银杏叶提取物，在欧洲广泛使用两年 几十年，将使因椎管狭窄而导致行走疼痛的患者受益 腿部的动脉。大约十年前在德国做的几项研究 似乎让这类患者受益。重要的是要证实这些发现 并了解它是如何工作的。动物研究表明，这种已知的提取物 作为银杏叶提取物761，通过非常强的抗氧化机制发挥作用。第二步行动 建议是刺激动脉内侧的细胞 产生一种化合物一氧化氮。这些细胞被称为内皮细胞，它们是 容易受到血液胆固醇、吸烟或高血压的损害， 当受损时，会使胆固醇沉积在动脉中。抗氧化剂可以 防止内皮细胞损伤，因此了解是否 银杏叶提取物761通过这种机制起作用。这些细胞还会产生一氧化氮。 天然地作为一种防御损伤，因此银杏叶提取物761对一氧化氮的影响 也会带来好处。

This application determines if a highly standardized herbal extract of the leaves of the Ginko biloba tree, widely used in Europe for two decades, will benefit patients who have pain on walking due to narrowing of the arteries of the legs. A few studies done about ten years ago in Germany appeared to benefit such patients. It is important to confirm these findings and to learn how it may work. Animal studies suggest that this extract, known as EGb 761, works through very strong antioxidant mechanisms. A second action suggested is that is stimulates cells lining the inside of the arteries to produce the compound nitric oxide. These cells, known as endothelial cells, are susceptible to damage by blood cholesterol, smoking or high blood pressure and, when damaged, will allow cholesterol to deposit in arteries. Antioxidants can prevent the endothelial cell damage, therefore it is very important to know if EGb 761 works through this mechanism. These cells also produce nitric oxide naturally as a defense against injury, so an EGb 761 effect on nitric oxide would also provide benefit.