EPILEPSY CLINICAL RESEARCH PROGRAM

该项目已涉及临床多个领域 多年来的研究，包括流行病学，外科手术， 癫痫的遗传学和药理学 流行病学研究 老年人的发病率和患病率最高 任何年龄组的癫痫，甚至高于儿童 片段 此外，老年人是增长最快的群体， 人口的一部分。 关于其影响，我们知之甚少。 老龄化，共同教育，并共同发病的药理学， 抗癫痫药物（AEDs）。 这5年的计划将使用 前几年发展的信息和专门知识， 抗癫痫药物在体外的代谢，在体内的大， 养老院老年人群，以评估AED使用的结局 并研究种族和性别对癫痫发展的影响。 我们的流行病学专业知识将用于评估共同- 癫痫和血管疾病的发病率使用ARIC数据库。 这项建议的一个主要优点是， 老年人，通过PCA在养老院中有60，000多名老年人， 贝弗利企业和16,000在ARIC数据库。 老年人 尤其是在这些疗养院， 和药物毒性，直到可以制定循证指南。

This program project has been involved in many areas of clinical research over the years, with activities in epidemiology, surgery, genetics and pharmacology of epilepsy. The epidemiological studies have shown that the elderly have the highest incidence and prevalence of epilepsy of any age group, even higher than in the pediatric segment. Furthermore, the elderly are the most rapidly growing segment of the population. Very little is known regarding the effect of aging, co-educations, and co-morbidity on the pharmacology of the antiepileptic drugs (AEDs). This 5 year proposal will use the information and expertise developed in previous years to study metabolism of antiepileptic medications in vitro, in vivo in a large, nursing home population of elderly, to evaluate outcomes of AED use and study race and gender effects on the development of epilepsy. Our epidemiological expertise will be used to evaluate the co- morbidity of epilepsy and vascular disease using the ARIC data base. A major strength of this proposal is the access to large groups of elderly, with over 60,000 elderly in nursing homes through PCA and Beverly Enterprises and 16,000 in the ARIC data base. The elderly especially in these nursing homes are vulnerable to improper AED use and drug toxicity until evidence based guidelines can be developed.