HISTOPATHOLOGY CBF AND NMR ASSESSMENT OF STROKE

描述：（逐字来自申请人的摘要）本发明的主要目标是： 建议是调查血流动力学因素在多大程度上参与了 增加的与缺血相关的组织损伤， 高血糖症全身血糖浓度升高已被 在实验性脑卒中后， 动物和人类。一些研究报道了脑血流量的变化 (CBF)与高血糖和CBF自动调节丧失相关， 可能是与以下疾病相关的不良结局的并发因素 脑血管病高血糖症。我们开发了一种新的高速 MRI技术连续监测CBF并生成初步数据 这表明，在大鼠脑中， D-葡萄糖输注与相关的短暂性自动调节丧失。这些 数据表明，血流动力学受损可能导致神经系统不良， 与高血糖卒中相关的结局。这项工作将提高我们的 了解高血糖在中风中的作用，可能有助于导致新的 中风管理的方法。

DESCRIPTION: (Verbatim from the Applicant's Abstract) The main goal of this proposal is to investigate to what extent hemodynamic factors are involved in increased tissue damage associated with ischemia under conditions of hyperglycemia. Elevated systemic blood glucose concentrations have been implicated in poor neurological outcome following stroke in experimental animals and humans. Some studies have reported changes in cerebral blood flow (CBF) associated with hyperglycemia and loss of CBF autoregulation has been implicated as a possible complicating factor in poor outcome associated with hyperglycemia in cerebrovascular disease. We have developed a new high-speed MRI technique to monitor CBF continuously and have generated preliminary data which indicate that in rat brain there is an acute increase in CBF with D-glucose infusion with an associated transient loss of autoregulation. These data suggest that impaired hemodynamics may contribute to poor neurological outcome associated with hyperglycemia stroke. This work will improve our understanding of the role of hyperglycemia in stroke and may help lead to new approaches for stroke management.