NEUROLOGIC & COGNITIVE ANALYSIS OF CALLOSOTOMY PATIENTS

痂体内有超过2亿根纤维连接着 大脑的两个半球，并在许多方面发挥作用 大脑半球间的整合。在经历了完整的 骨痂切开术，这条综合通路被切断了，但这些患者 在日常生活中非常不受影响。在过去，分裂大脑 研究已经阐明了许多偏侧化和专门化的 大脑两个半球的功能。目前的建议是 旨在扩大这一重点，不仅研究半球 专业化，也是跨半球的融合。建议 实验考察了知觉和认知的程度 各功能在膝盖骨上是协调的。我们假设有 基本视觉和大脑半球之间的功能重复 注意过程，因此这些过程不依赖于 膝盖骨整合。相反，我们假设更高的水平 知觉和认知功能涉及大脑半球的特化 并因此依赖于胼胝体的整合路径。值得注意的是， 在二十多年的胼胝体功能研究中， 基本假设还没有经过严格的检验。具体来说， 我们将研究整合的可能的非膝盖骨通路 整个半球的形状和位置信息，更新 当眼球运动发生时，每个半球的视觉空间地图，以及 注意力分配的方式。可能的膝盖骨相互作用 对于感知和记忆过程的研究将通过研究 合成过程中视觉系统对轮廓片段的结合 对象感知，以及内存中事件元素的绑定 编码。

The corpus callosum contains more than 200 million fibers connecting the two hemispheres of the brain, and plays a role in many aspects of interhemispheric integration. In patients who have undergone complete callosotomy, this integrative pathway is severed and yet these patients are remarkably unaffected in daily living. In the past, split-brain research has elucidated many of the lateralized and specialized functions of the two hemispheres of the brain. The current proposal is aimed at expanding this focus to study not only hemispheric specialization but also interhemispheric integration. Proposed experiments investigate the extent to which perceptual and cognitive functions are coordinated callosally. We hypothesize that there is duplication of function between the hemispheres in basic visual and attentional processes and therefore these processes do not rely on callosal integration. In contrast, we hypothesize that higher level perceptual and cognitive functions involve hemispheric specialization and therefore depend on callosal pathways for integration. Remarkably, in more than twenty years of research on callosal function, these fundamental hypotheses have not been rigorously tested. Specifically, we will investigate possible non-callosal pathways for the integration of form and location information across the hemispheres, the updating of each hemisphere's map of visual space when eye motions occur, and the ways in which attention is allocated. Possible callosal interactions for perceptual and memory processes will be investigated by studying the binding of contour fragments by the visual system in the synthesis of object percepts, and the binding of elements of events in memory encoding.