Core--Animal facility

ANIMAL CORE的目的是为本项目的研究人员提供科学和技术支持，帮助他们设计和执行研究。该核心的具体目标是：1。1 .诱导动物患上糖尿病，并使动物保持健康状态（定期监测是否符合糖尿病动物的健康标准），并严格控制血糖水平。2 .协调项目研究人员从实验动物身上获取和分配组织和体液；3 .为动物特殊饮食和药物治疗方案的科学和执行提供协助；为该项目的新研究人员提供糖尿病及其并发症动物模型的使用培训。为项目研究人员提供的服务将由我们的动物研究部门主任（V. Monnier， MD， T. Kern, PhD）和一个60% FTE的研究助理组成，该研究助理将与CWRU动物资源中心的工作人员合作，承担设施的日常运营。

Summary ANIMAL CORE The objective of the Animal Core is to provide investigators of the Program Project with scientific and technical support for the design and execution of their studies. The specific aims of this core are: 1. To induce diabetes in animals and maintain the animals in a healthy state (routinely monitored for compliance with standards of health appropriate for diabetic animals) and in carefully controlled levels of glycemic control, 2. To coordinate the acquisition and distribution of tissues and body fluids from experimental animals among Program Project investigators, 3. To provide assistance with scientific and execution of protocols involving special diet and pharmacological treatments in animals, and 4. To provide training for new investigators of the Program Project in the use of animal models of diabetes and its complications. Service to the Investigators of the Program Project will be provided by a team consisting of the director of our unit for animal studies (V. Monnier, MD, T. Kern, PhD), and a 60% FTE Research Assistant who will assume the day-to-day operation of the facility in collaboration with the staff of the Animal Resources Center at CWRU).