Phytoestrogens and innate immunity in ER deficient mice

产品描述：本项目的目标是确定植物雌激素（染料木黄酮，黄苷元和大豆提取物）通过雌激素受体依赖性和非依赖性途径对先天免疫功能的作用范围和机制。这一目标将使用肠道、肝脏和脾脏中细菌炎症的雌激素受体缺陷（ERKO）严重联合免疫缺陷（SCID）小鼠模型来实现。假设雌激素和植物雌激素信号是巨噬细胞和自然杀伤细胞功能的正调节剂。具体来说，该项目将：1）确定雌激素受体α信号转导的损失对细菌诱导的炎症的影响。2)确定雌激素受体β信号传导的丧失对细菌诱导的炎症的影响。3)确定雌激素受体α和β信号转导的丧失对细菌诱导的炎症的影响。

Description: The goal of this project is to determine the range and mechanism of action of phytoestrogens (genistein, diadzein and soy extracts) on innate immune function via estrogen receptor-dependent and independent pathways. This goal will be accomplished using estrogen receptor deficient (ERKO) severe combined immunodeficient (SCID) mouse models of bacterial inflammation in the gut, liver and spleen. The hypothesis is that estrogen and phytoestrogen signaling is a positive regulator of macrophage and natural killer cell function. Specifically, this project will: 1) Determine the effects of the loss of estrogen receptor alpha signaling on bacterial-induced inflammation. 2) Determine the effects of the loss of estrogen receptor beta signaling on bacterial-induced inflammation. 3) Determine the effects of the loss of estrogen receptors alpha and beta signaling on bacterial induced inflammation.