CORE--ECOGENETICS RESEARCH FACILITY

这一核心将集中在遗传易感性在毒素中的作用 对环境代理人的回应。其宣称的远景目标是“实现 识别和表征与基因差异有关的遗传多态 对环境因素的反应-反应也包括肿瘤形成 急性和慢性毒性。有六个明确的目标 本研究的核心是：1)阐明基因表达的机制和 通过遗传变异进行调控；2)筛选种群和三个- 代家系对毒性反应的差异；3)确定 遗传基因座与表型性状之间的关联；4) 了解多态的分子基础；5)研究 胚胎发育过程中基因和试剂的相互作用；6)评估 每种多态对人类健康的影响。

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, "to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity." There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.