CORE--NEUROTOXICOLOGY

研究人员在研究核心4中进行的研究旨在描述遗传、衰老和环境在神经退行性疾病发病机制中的相互作用，并阐明某些神经毒物的作用机制。研究核心的目标是继续促进实验室研究人员与参与人类研究的同事之间的整合，促进神经退行性疾病中环境和遗传风险因素的新项目的发展，并开发一个供中心研究人员使用的啮齿动物行为实验室。神经毒理学研究核心由来自环境卫生、神经外科、病理学、医学遗传学和流行病学部门的八名调查员，来自华盛顿大学环境卫生、神经病学和生物工程部门的五名附属调查员，以及来自外部研究机构的调查员组成。除了广泛参与神经毒理学的重大问题外，Costa博士还与Furlong博士合作探索对氧磷酶的遗传多态性和对有机磷杀虫剂的易感性，并与Checkoway博士合作研究单胺氧化酶B和D2受体的多态性作为帕金森病的危险因素。布巴切尔博士继续研究铅对非人类灵长类动物的发育毒性，并承担了建立啮齿动物行为实验室的任务。科斯塔和弗朗，在吉尔伯特博士离开大学之后。马丁博士的加入为阿尔茨海默病的研究提供了额外的力量。研究人员开展了广泛的合作，并在他们的合作研究中利用了设施核心。未来的计划包括促进核心研究人员之间的互动，实施啮齿动物行为实验室，在神经毒理学社区培养生态遗传学的概念，促进核心研究人员的研究，开发神经退行性疾病的遗传和环境风险项目，并催化额外的合作和刺激新的研究方向。

Description: The research conducted by investigators in Research Core 4 seeks to characterize the interplay between genetics, aging, and the environment in the pathogenesis of neurodegenerative diseases, as well as to elucidate the mechanism of action of certain neurotoxicants. The goals of the Research Core are to continue to facilitate the integration between laboratory investigators and colleagues involved in human studies, to foster the development of a new program project on environmental and genetic risk factors in neurodegenerative diseases, and to develop a rodent behavioral laboratory for use by Center investigators. The Neurotoxicology Research Core consists of eight Investigators, from the Departments of Environmental Health, Neurological Surgery, Pathology, Medical Genetics, and Epidemiology, five Affiliate Investigators from the Departments of Environmental Health, Neurology, and Bioengineering at the University of Washington, and investigators from outside research institutions. In addition to broad involvement in major issues in neurotoxicology, Dr. Costa collaborates with Dr. Furlong exploring genetic polymorphisms in paraoxonase and susceptibility to organophosphorus insecticides and with Dr. Checkoway on polymorphisms of monoamine oxidase B and D2 receptors as risk factors in Parkinson's disease. Dr. Burbacher continues his studies of developmental toxicity of lead in non-human primates and has taken on the task of developing a rodent behavioral laboratory, with Drs. Costa and Furlong, following the departure of Dr. Gilbert from the university. The addition of Dr. Martin to the research core has provided additional strength in Alzheimer's disease. The investigators have developed extensive c9ollaborations and have utilized the facility cores in their collaborative research. Future plans include the stimulation of increased interactions between Core investigators, implementation of a rodent behavioral laboratory, fostering the concept of ecogenetics in the neurotoxicology community, facilitating research by the Core investigators, developing a program project in genetic and environmental risk in neurodegenerative diseases, and catalyzing additional collaborations and stimulating new lines of research.