STIMULATION OF HUMAN CORONARY ANGIOGENESIS WITH BASIC FGF

本研究的目的是要基本达到临床疗效。 成纤维细胞生长因子在冠状动脉血管生成中的作用 慢性心肌缺血。以缺血性冠心病居首 导致西方世界疾病和死亡的原因。最可用的 治疗方法的目的要么是通过减少 心肌耗氧量，通过以下方式防止疾病进一步发展 修改风险因素，恢复流向 动脉树(血管成形术)或旁路梗阻(搭桥手术)。 然而，还没有任何尝试恢复对 通过为心肌提供新的血液流动场所。治疗性的 血管生成可能服务于这一目标。血管生成是一个复杂的过程 涉及内皮细胞和平滑肌细胞的增殖和迁移， 形成新的毛细血管，分解现有的细胞外基质 并形成一个新的。相对较少的人知道关于 这一过程的生理意义和治疗潜力 慢性心肌缺血与其相关的分子细胞事件 人们对监管知之甚少。利用动物进行初步调查 模型表明，碱性成纤维细胞生长因子可用于生理刺激。 心肌缺血时的显著血管生成。然而，到目前为止，那里 一直没有在患者身上使用这种生长因子的经验。这个 因此，本研究将检查3个具体目标：1.血管生成 碱性成纤维细胞生长因子对慢性心肌缺血的疗效；II.磁的作用 磁共振成像在冠状动脉血管生成的无创性评估中的应用 其他酪氨酸激酶配体在促进血管生成中的作用评价 在慢性心肌缺血时。

The purpose of the present study is to the clinical efficacy of basic fibroblast growth factors (bFGF) in coronary angiogenesis in the setting of chronic myocardial ischemia. Ischemic coronary disease is the leading cause of morbidity and mortality in the Western world. Most available therapeutic approaches aim either at relieving symptoms by reducing myocardial oxygen demand, preventing further disease progression by modifying risk factors, restoring flow to a localized segment of the arterial tree (angioplasty) or bypassing obstruction (bypass surgery). However, no attempts have been made to restore blood supply to the myocardium by providing new venues for blood flow. Therapeutic angiogenesis may serve this goal. Angiogenesis is a complex process involving endothelial and smooth muscle cell proliferation and migration, formation of new capillaries, breakdown of existing extracellular matrix and formation of a new one. Relatively little is know regarding physiological importance and therapeutic potential of this process in chronic myocardial ischemia and molecular cellular events involved in its regulation are poorly understood. Preliminary investigation using animal models have shown that bFGF can be used to stimulate physiologically significant angiogenesis in myocardial ischemia. However, to date there has been no experience with the use of this growth factor in patients. The present study, therefore, will examine 3 Specific Aims: I. Angiogenic efficiency of bFGF chronic myocardial ischemia; II. Role of magnetic resonance imaging in noninvasive assessment of coronary angiogenesis; III. valuation of other tyrosine kinase ligands in stimulation of angiogenesis in chronic myocardial ischemia.