FRAGILE ANIMAL MODELS OF HUMAN DISEASE: AIDS

核心单位-灵知生物学和诊断实验室服务 核心单位将以高度互动和 建立在协作基础上。将提供四种基本类型的服务。 1.灵知生物学技术服务--包括无菌服务 隔离器的制造、修改和设计及安装 啮齿动物。将为设计提供技术专业知识和支持， 特制高效空气过滤器的施工、使用和维护 用于安置免疫功能低下的狗和灵长类动物的围栏。 将提供净化和后勤支助，以及 高压灭菌和净化设备、食物、水和其他 补给。啮齿动物剖腹产及其他特殊操作 将会被提供。 2.无菌和灵生啮齿类动物住房--常规饲养 (喂食、浇水、更换笼子等)将为所有啮齿动物提供 在无菌隔离器中。将提供类似的管理和护理 SCID啮齿动物在被安置在特殊的HEPA过滤围栏中时正在研究 生物系动物设施。核心将与 高校实验动物资源与动物保育相关活动 视需要而定。 3.诊断实验室服务--现有的研究实验室设施 在实验动物医学和兽医病理生物学方面将提供 诊断支持。这一支持将描述和确保微生物 研究中使用的动物状况，并将进行调查和保证 无菌隔离器的适宜环境条件 经过过滤的围栏，以及动物所在的其他区域 有房住。 4.行政支助--核心将提供行政支助 项目负责人，并将协调所有动物护理和使用事宜 适当的大学办公室。

Core Unit- Gnotobiology and Diagnostic Laboratory Services The core unit will serve all projects in a highly interactive and collaborative basis. Four basic types of services will be provided. 1. Technical Services for Gnotobiology- This will include germ free isolator fabrication, modification and design and set-up as required for rodents. Technical expertise and support will be provided for the design, construction, manipulation and maintenance of special HEPA filtered enclosures for housing immunocompromised dogs and primates. Decontamination and logistical support will be provided, as well as autoclaving and decontaminating equipment, food, water, and other supplies. Cesarean derivation of rodents and other special manipulation will be provided. 2. Housing for Germ free and Gnotobiotic Rodents- Routine husbandry (feeding, watering, cage changing, etc.) will be provided for all rodents in germ free isolators. Similar husbandry and care will be provided for SCID rodents on study while housed in special HEPA filtered enclosures in the Department of Biology animal facility. The core will coordinate with University Laboratory Animal Resources on animal care related activities as required. 3. Diagnostic Laboratory Services- Existing research laboratory facilities in Laboratory Animal Medicine and in Veterinary Pathobiology will provide diagnostic support. This support will characterize and assure microbial status of animals used in the studies and will survey and assure appropriate environmental conditions for germ free isolators, HEPA filtered containment enclosures, and other areas in which animals are housed. 4. Administrative Support- The core will provide administrative support to project leaders and will coordinate all animal care and use matters with appropriate university offices.