REPRODUCTIVE SCIENCES RESEARCH CAREER DEVELOPMENT CENTER

近年来，科学家和临床研究人员越来越重视女性的生殖健康，美国医学院的妇产科学部门正在努力满足这一需求。在过去十年中，在生殖科学领域获得亚专业奖学金和从事研究工作的医生人数明显减少。此外，由于临床需求增加和对科学职业发展的财政支持减少，很难将训练有素的年轻研究人员留在医学院。本申请的目的是在妇产科的基础研究和转化研究项目中建立一个多学科的生殖科学研究职业发展中心，致力于培养一支训练有素、独立资助的临床科学家队伍，研究妇女健康的关键领域。在五个重点研究中心（神经内分泌、卵巢、胎儿生理学、肥胖/代谢和流行病学）的基础科学研究基础上，该中心将监督这些学者发展成为成熟的研究人员，为在著名研究型大学任职做好充分准备。一个由监督和指导两阶段的学习计划将辅以个性化课程、研讨会和教程，内容涵盖生物统计学、临床研究方法学、流行病学、结果分析、伦理学、药理学和分子遗传学。该中心的独特之处在于将学者与选定的转化研究合作者联系起来，这些合作者将协助学者在与其基础科学重点相关的临床领域进行和发表研究。为了确保所有学者在现代研究技术方面发展初步能力，建议建立一个教学分子生物学核心实验室，由一位资深教授组成，在基本的实验室程序中提供个性化的指导。在整个4-5年的项目中，该中心的教师将提供持续的教程，让学者们在拨款写作技巧、临床研究方法、实验结果的出版和展示、卫生保健服务组织和经济学等领域积累知识。

In recent years, there has been a growing emphasis on women's reproductive health scientists and clinical researchers is greatest departments of obstetrics and gynecology in U.S. medical schools are struggling to meet the need. Over the past decade, there has been a marked decline in the number of physicians entering subspecialty fellowships and research careers in the reproductive sciences. Further, retention of well-trained young investigators on medical school faculties has been difficult because of increased clinical demands and diminishing fiscal support for scientific career development. The aims of this application is to establish, within a department of Obstetrics and Gynecology with well-recognized programs in basic and translational research, a multi-disciplinary Reproductive Sciences Research Career development enter dedicated to developing a cadre of broadly trained, independently funded clinician-scientists investigating key areas of women's health. Building on basic science research in five emphasis-center (neuroendocrine, ovarian, fetal physiology, obesity/metabolism and epidemiology) with eminent mentors, the Center will oversee the Scholars' evolution into mature investigators fully prepared for tenure in prominent research universities. A two-phase program of supervised, then mentored learning will be supplemented with individualized courses, seminars and tutorials covering biostatistics, clinical research methodology, epidemiology, outcomes analysis, ethics, pharmacology, and molecular genetics. Unique aspects of the proposed Center include the linkage of Scholars with selected Translational Research Collaborators who will assist Scholars in conducting and publishing research in clinical areas relevant to their basic science focus. To ensure that all Scholar's develop initial competence in modern research techniques, a Teaching Molecular Biology Core Laboratory is proposed, staffed by a senior professor, to provide individualized instruction in essential laboratory procedures. Throughout the 4-5 year program, the enter's Faculty will conduct ongoing tutorials in which Scholars will build knowledge in the areas of grant-writing skills, clinical research methodology, publication and presentation of experimental findings, and health care delivery organization and economics.