PHYSICIAN SCIENTIST TRAINING GRANT IN ONCOLOGY
PHYSICIAN SCIENTIST TRAINING GRANT IN ONCOLOGY
批准号:
6375471
负责人:
CHRIS H. TAKIMOTO
金额:
$42.47万
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-05 至 2003-06-30
中文摘要
许多机构可以培养出优秀的临床肿瘤学家,
然而,很少有机构具备所需的必要要素,
培养这些年轻的临床医生从事调查工作。San
安东尼奥有很长的历史,煮沸的基础和临床癌症
研究并在合作小组中发展了主要的专门知识
临床试验、研究药物开发、乳腺癌研究、
和骨髓移植为了在这些领域取得卓越成就,
基础和临床研究人员密切合作。
近日,通过与美国德克萨斯大学的共同努力,
健康科学中心(UTHSCSA)与癌症治疗和研究
中心(CTRC),癌症研究工作已组织成
圣安东尼奥癌症研究所(SACI),NCI指定的综合性
癌症中心如本申请中所述,圣安东尼奥可以
为学员提供适当的研究经验,教学
指导和指导,以开始临床癌症的职业生涯
research.我们的计划将确定医生候选人学员
从内科手术和放射肿瘤学一个咨询
由SACI主要成员和临床主席组成的委员会
UTHSCSA将为培训计划提供监督。学员
将获得两年的培训补助金。每个学员
将选择一名SACI成员作为他们培训的导师,
实验室研究技能。一旦选定,研究委员会将
对受训者的进度进行详细的监督。
在研究支持的第一年结束时,学员将
提交临床研究提案。该提案将
旨在产生足够的数据来启动他们的研究
事业在两年的支持结束后,
到他们的临床部门担任初级教员,
他们的职业发展。因此,该培训计划将允许
年轻的临床医生发展一个研究领域的专业知识,并带来
将这些专业知识带回他们的“家庭”临床部门。
英文摘要
Many institutions can train outstanding clinical oncologists,
however, few institutions contain the necessary elements required
to train these young clinicians for a career in investigation. San
Antonio has a long history of boil basic and clinical cancer
research and has developed major expertise in cooperative group
trials, investigational drug development, breast cancer research,
and bone marrow transplant. To obtain excellence in these areas,
basic and clinical investigators have worked closely together.
Recently, through the joint efforts of the University of Texas
Health Science Center (UTHSCSA) and the Cancer Therapy and Research
Center (CTRC), the cancer research efforts have been organized into
San Antonio Cancer Institute (SACI), an NCI designated comprehensive
cancer center. As described in this application, San Antonio can
provide trainees with appropriate research experience, didactic
instruction, and mentoring to begin a career in clinical cancer
research. Our program will identify physician candidate trainees
from medical, surgical, and radiation oncology. An Advisory
Committee composed of key members of SACI and the clinical chairs
of UTHSCSA will provide oversight for the training program. Trainees
will be supported for two years on this training grant. Each trainee
will select a SACI member as a mentor for their training in
laboratory research skills. Once selected, Research Committee will
be formed to provide detailed oversight of the trainee's progress.
At the end of the first year of research support, the trainee will
submit a clinical investigation proposal. The proposal will be
designed to generate sufficient data to launch their research
career. At the end of two years of support, th trainee will return
to their clinical department as junior faculty members to continue
their career development. Thus, this training program will allow
young clinicians to develop an area of research expertise and bring
this expertise back to their "home" clinical department.
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A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay.
基于新的生物素化培养地扩展测定法,用于研究端粒酶抑制剂的人类乳腺癌模型。
DOI:
10.1038/sj.bjc.6690526
发表时间:
1999-07
期刊:
BRITISH JOURNAL OF CANCER
影响因子:
8.8
作者:
[Raymond, E, Sun, D, Izbicka, E, Mangold, G, Silvas, E, Windle, B, Sharma, S, Soda, H, Laurence, R, Davidson, K, Von Hoff, DD]
通讯作者:
Von Hoff, DD
Dimethyl sulfoxide (DMSO) causes a reversible inhibition of telomerase activity in a Burkitt lymphoma cell line.
二甲亚砜 (DMSO) 可逆性抑制伯基特淋巴瘤细胞系中的端粒酶活性。
DOI:
10.1016/s0145-2126(97)00188-4
发表时间:
1998
期刊:
Leukemia research
影响因子:
2.7
作者:
[Sharma,S, Raymond,E, Soda,H, Izbicka,E, Davidson,K, Lawrence,R, VonHoff,DD]
通讯作者:
VonHoff,DD
DOI:
10.1182/blood.v87.4.1495.bloodjournal8741495
发表时间:
1996-02-15
期刊:
BLOOD
影响因子:
20.3
作者:
[Alsina, M, Boyce, B, Roodman, GD]
通讯作者:
Roodman, GD
An in vivo model of human multiple myeloma bone disease.
人类多发性骨髓瘤骨病的体内模型。
DOI:
--
发表时间:
1995
期刊:
Stem cells (Dayton, Ohio)
影响因子:
--
作者:
[Alsina,M, Boyce,BF, Mundy,GR, Roodman,GD]
通讯作者:
Roodman,GD
Phase II study of flutamide as second line chemotherapy in patients with advanced pancreatic cancer.
氟他胺作为晚期胰腺癌患者二线化疗的 II 期研究。
DOI:
10.1023/a:1005989519350
发表时间:
1997
期刊:
Investigational new drugs
影响因子:
3.4
作者:
[Sharma,JJ, Razvillas,B, Stephens,CD, Hilsenbeck,SG, Sharma,A, Rothenberg,ML]
通讯作者:
Rothenberg,ML
共 8 条
PH I STUDY OF BMS-247550 GIVEN ON CONTINUOUS WEEKLY SCHEDULE IN PTS W/ADV MALIG
-
批准号:7378182
-
项目类别:
-
资助金额:$0.36万
-
财政年份:2006
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
PH I PK STUDY OF PS341 IN PTS WITH ADVANCED MALIGNANCIES AND RENAL DYSFUNCTION
-
批准号:7204786
-
项目类别:
-
资助金额:$0.48万
-
财政年份:2005
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
PH I STUDY OF BMS-247550 GIVEN ON CONTINUOUS WEEKLY SCHEDULE IN PTS W/ADV MALIG
-
批准号:7204785
-
项目类别:
-
资助金额:$1.05万
-
财政年份:2005
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
Ph I Pharmacokinetics of STI571 in Cancer & Liver Dis
-
批准号:6972381
-
项目类别:
-
资助金额:$1.05万
-
财政年份:2004
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
Ph I Pharmacokinetics of STI571 in Neoplasms/kidney Dis
-
批准号:6972382
-
项目类别:
-
资助金额:$0.36万
-
财政年份:2004
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
ERBB1 AND ERBB2 BLOCKADE IN ADVANCED BREAST CANCER
-
批准号:6867516
-
项目类别:
-
资助金额:$26.41万
-
财政年份:2002
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
PHARMACOLOGIC AND PHASE I STUDIES OF NEW AGENTS FOR THE TREATMENT OF SOLID TUMORS
-
批准号:6123768
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
Preclinical & clinical pharmacology of agents in GI malignancies: topoisomerase I
-
批准号:6312281
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
PRECLINICAL AND CLINICAL PHARMACOLOGY OF PROMISING AGENTS IN GI MALIGNANCIES
-
批准号:6123767
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
PHARMACOLOGIC AND PHASE I STUDIES OF NEW AGENTS FOR THE TREATMENT OF HUMAN SOLID
-
批准号:6290856
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CHRIS H. TAKIMOTO
-
依托单位:
海外基金