WADSWORTH CTR: INFECTIOUS DIS, WEST NILE, AIDS, MALARIA, TB, BIOTERRORISM, LYME

描述(申请人提供)：世界卫生组织正在建立一个国家认可的节肢动物传播疾病研究中心。自1999年以来，已经招募了五名杰出的科学家，他们将领导该计划。该项目正在合并到GL校区的四栋相邻建筑中(这是一个建于1930年S的建筑群，由九栋建筑组成)。大约10,000平方米英国《金融时报》修复了其中两栋建筑的空间，耗资750万美元，以建立节肢动物传播疾病的专门研究实验室。正在寻求资金，与邻近的动物和实验室空间建立一个生物遏制昆虫；这是在节肢动物传播的病毒、细菌和寄生虫病的广泛研究计划中实现卓越的必要条件。在拟议的翻修中，包括生物安全二级(BSL2)和BSL3级杀虫剂，总面积为2750平方英尺。英国《金融时报》拟议中的设施将是东北部最大的以研究为导向的BSL3昆虫，能够在地区和国家范围内开展广泛的合作项目。为WC调查人员及其合作者提供的支持节肢动物相关研究的外部资金已达到约690万美元，并预计将随着只有拟议设施才能实现的个人和合作项目的发展而大幅扩大。具体目标包括：1)建立BSL2昆虫和邻近的动物设施，以维持节肢动物群体，以及BSL3昆虫和动物设施，以处理受感染的节肢动物；2)建造两个相邻的厕所研究实验室，并合作研究人员进行昆虫相关研究；以及3)安装新的供暖、通风和空调系统，以控制整个设施的温度和湿度。

DESCRIPTION (provided by applicant): The WC is establishing a nationally recognized center in arthropod-borne disease research. Since 1999, five exceptional scientists have been recruited who will lead the program. The program is being consolidated into four adjacent buildings on the GL campus (a complex of nine buildings constructed in the 1930's). Approximately 10,000 sq. ft. of space has been rehabilitated in two of these buildings, at a cost of $7.5 million, to create dedicated research laboratories for arthropod-borne diseases. Funds are being sought to create a biocontainment insectary with adjacent animal and laboratory space; this is a necessity to achieve excellence in broad research programs on arthropod-borne viral, bacterial and parasitic diseases. Among the proposed renovations are Biosafety Level 2 (BSL2) and BSL3 insectaries totaling 2,750 sq. ft. The proposed facility will be the largest research-oriented BSL3 insectary in the Northeast, capable of extensive collaborative programs regionally and nationally. External funding to support arthropod-related research for the WC investigators and their collaborators has reached approximately $6.9 million and is expected to expand significantly upon the development of individual and collaborative programs that are possible only with the proposed facility. Specific Aims include: 1) creation of a BSL2 insectary and adjacent animal facilities for maintenance of arthropod colonies, and a BSL3 insectary and animal facilities for work with infected arthropods; 2) construction of two adjacent research laboratories for WC and collaborating investigators to conduct insectary-related research; and 3) installation of a new heating, ventilation, and air-conditioning (HVAC) system for control of temperature and humidity throughout the facility.