MAGNETIC RESONNANCE CTR: PROTEIN STRUCT, TUBERCULOSIS, MOLEC PROBE SYNT

描述（由申请人提供）：资金要求建设一个1,300平方米。英尺NMR大楼毗邻加州大学洛杉矶分校分子S大楼一楼的现有仪器设施。该建筑将用于容纳高场NMR光谱仪（600 MHz和1 MHz）。现有的仪器实验室没有空间容纳新的600兆赫高场分光计，即使现有的仪器可以搬迁，也没有足够的空间容纳800兆赫分光计。因此，这座建筑对于扩大UCLA的NMR设施至关重要，这是支持医学和生物化学前沿的生物医学研究人员所必需的。该设施将是独一无二的，它将物理化学家，有机化学家，结构生物学家，生命科学家和医学院的教师聚集在一起，使用NMR光谱来解决问题。将受益于NMR资源的具体研究领域是蛋白质，核酸和复合物的结构生物学，大分子相互作用和动力学，结构基因组学，合成有机分子，大分子组装和天然产物的表征，以及生物分子成像。

DESCRIPTION (provided by applicant): Funds are requested for the construction of a 1,300 sq. ft. NMR building adjacent to the current instrumentation facilities on the first floor of the Molecular S Building at UCLA. This building will be used to house high field NMR spectrometers (600 MHz an MHz). There is no room in the existing instrumentation laboratories to house new high field spectrometer at 600 MHz and no adequate space to house an 800 MHz spectrometer even if current instrumentation could be relocated. Thus, this building is essential for the expansion of NMR facilities at UCLA, which is needed to support biomedical researchers at the forefront of medicine and biochemistry. This facility will be unique in bringing together physical chemists, organic chemists, structural biologists, life scientists, and faculty in the school of medicine to solve problems using NMR spectroscopy. Specific research areas that will benefit from the NMR Resource are structural biology of proteins, nucleic acids, and complexes, macromolecular interactions and dynamics, structural genomics, characterization of synthetic organic molecules, macromolecular assemblies, and natural products, and biomolecular imaging.