ENANTIOPURE ORGANOMETALLICS FOR ASYMMETRIC SYNTHESIS

在有机金属配合物催化的反应中，不对称的一个常见来源是附着在金属中心的手性配体中的手性。本文所述的研究计划提出，配体手性可以用来控制衍生催化剂配合物中其他不常用的手性元素（平面和金属中心）。成功结合所有这三种立体控制元素的有机金属物种预计在制备功能性、对映异构富集的有机化合物的通用反应中具有广泛的适用性，并且同时可以随时获得重要的生物活性天然物质和产物（例如，细胞毒性和抗真菌剂）。详细了解这些新复合物的特征及其介导的反应机制将证明对开发有效和有用的工艺至关重要。

A common source of asymmetry in reactions catalyzed by organometallic complexes is the chirality resident in chiral ligands attached to the metal center. The research plan described herein proposes that ligand chirality can be used to control other less frequently employed elements of chirality (planar and metal-centered) in the derived catalyst complexes. Organometallic species that successfully incorporate all three of these stereocontrol elements are predicted to possess broad applicability in reactions of general utility for the preparation of functional, enantiomerically enriched organic compounds and should concurrently allow ready access to important biologically active natural and products (e.g., cytotoxic and antifungal agents). A detailed understanding of the characteristics of these new complexes and the mechanisms of the reactions they mediate will prove crucial in the development of efficient and useful processes.