CLONING THE POLAR LETHAL OVUM MUTANT GENE OF THE MOUSE

描述（改编自研究者摘要）：当DDK的女性 近交系小鼠品系与许多其他近交系的雄性交配， 大多数所产生的胚胎在植入前发育期间死亡。的 相互交配，DDK男性和女性之间的其他近交系是 完全可行。这种致命特征的母体和父体成分 分离为两个紧密连锁的基因座。在过去的三年里，我们 成功地将这些基因定位到一个小区域（约300 小鼠11号染色体的DNA序列。这些基因的分离应该允许 确定母亲和父亲的基因如何相互作用，从而导致 植入前胚胎的死亡，以及这种相互作用如何导致 11号染色体的优先分离（减数分裂驱动） 杂合子女性这些基因的分离也将允许 研究非孟德尔遗传的、依赖于父母起源的、 这一特点已经实现。

DESCRIPTION (Adapted from investigator's abstract): When females of the DDK inbred mouse strain are mated to males of many other inbred strains, the vast majority of the resulting embryos die during preimplantation development. The reciprocal matings, between DDK males and females of other inbred strains are fully viable. The maternal and paternal components of this lethal trait segregate as two closely-linked loci. Over the last three years, we have succeeded in localizing these genes to a small area (approximately 300 kilobases) of mouse chromosome 11. The isolation of these genes should allow a determination of how the maternal and paternal genes interact to result in the death of preimplantation embryos and, perhaps, how this interaction results in the preferential segregation of chromosomes 11 (meiotic drive) among heterozygous females. The isolation of these genes will also allow an investigation of how the non-Mendelian, parental-origin dependent, transmission of this trait is achieved.