MICHIGAN PREVENTION RESEARCH CENTER

密歇根州预防研究中心的这一竞争性更新提案代表了长期协调研究计划的下一步，该计划旨在预防心理脆弱的个人和家庭经历工作过渡和经济压力时的情绪和行为障碍。 我们建议继续密歇根州预防研究中心的预防研究计划，新的重点是减少抑郁症及其复发和相关残疾和其他并发疾病的风险。 此外，我们建议将我们的重点从失业扩大到包括更广泛的弱势个人和面临风险的家庭。 为了实现这一目标，我们建议继续密歇根州预防研究中心（MPRC）作为预防研究的国家资源，提供科学基础设施，进行随机对照现场试验，测试预防方案的功效，有效性和成本效益。 该方案将通过实施四个相互关联的具体目标来实施，每个目标由一个核心代表。 这些核心旨在为以下领域提供高质量的科学基础设施：（1）对有各种精神脆弱迹象的高危个人和家庭成员以及正在应对经济困难压力的家庭进行预防性干预措施的功效试验，（2）在社区和服务系统中进行试验，以测试先前证明有效的预防性干预措施的功效和成本效益，3）支持国家在预防性试验的测量，分析和数据管理方面的方法进步能力，为全国MPRC研究人员和预防科学家提供服务，以及4）为研究规划，社区合作和指导提供基础设施。

This competing renewal proposal for the Michigan Prevention Research Center represents the next step in a long term coordinated program of research on the prevention of emotional and behavioral disorders in psychologically vulnerable individuals and families experiencing work transitions and economic stress. We propose to continue the program of prevention research of the Michigan Prevention Research Center with a new expanded emphasis on the reduction of risks for depression and its recurrence and associated disability and other co-occurring illnesses. In addition, we propose to expand our focus from job loss to include a wider range of vulnerable individuals and families who are at risk. In order to accomplish this, we propose to continue the Michigan Prevention Research Center (MPRC) as a national resource for prevention research providing scientific infrastructure to conduct randomized controlled field trials testing the efficacy, effectiveness and cost effectiveness of preventive programs. The program will be carried out by implementing four interlocking specific aims, each represented by a core. The cores are designed to provide high quality scientific infrastructure for: 1) conducting efficacy trials of preventive interventions with high risk individuals and families whose members show various signs of psychiatric vulnerability and who are coping with the stresses of economic hardship, 2) implementing trials to test the effectiveness and cost effectiveness of previously proven preventive interventions in communities and service systems, 3) supporting a national capacity for methodological advances in measurement, analysis and data management for preventive trials, serving both MPRC researchers and prevention scientists nationwide, and 4) providing the infrastructure for research planning, community collaboration and mentoring.