HELPER T CELL SUBPOPULATION ACTIVITIES IN HIV DISEASE

艾滋病毒疾病的一个主要并发症是呼吸状况恶化，这通常是由过敏引起的。这是一项试验性研究，旨在确定IgE介导的呼吸与HIV血清转换和疾病进展相关的流行率，并测试标准变应原免疫疗法在这些HIV+患者中的安全性。已有四名患者参加了这项研究，其中一名患者已经完成了研究。这些受试者有严重的常年性变应性鼻炎病史，对药物治疗反应不佳。他们开始每周一次的AIT，并监测CD4种群、病毒载量和体外细胞因子的产生。结果显示，CD4计数保持稳定，血浆病毒载量仍未被检测到。体外破伤风诱导的IFNG水平升高，而IL-4和IL-10水平相对不变。临床反应显著，症状评分下降，不再需要常规药物治疗。这些数据表明，AIT可能在选定的HIV+患者中有用，并支持需要一项更大规模的对照试验，以确定哪些HIV+患者可能从这种疗法中受益。

A major complication of HIV disease is worsening respiratory conditions, which are often of allergic origin. This is a pilot study to identify prevalence of IgE-mediated respiratory correlated with HIV seroconversion and disease progression, and to test the safety of a standard allergen immunotherapy regimen in these HIV+ patients. Four patients have been enrolled in the study, and one has completed the study. These subjects have a history of severe perennial allergic rhinitis poorly responsive to medical therapy. They started weekly AIT and were monitored for CD4 populations, viral load and in vitro cytokine production. Results showed CD4 counts remained stable and plasma viral load remained undetectable. The in vitro tetanus-induced IFNg levels increased while IL-4 and IL-10 levels remained relatively unchanged. Clinical response has been remarkable, with symptom scores demising and need for regular medications no longer necessary. These data suggest that AIT may have utility in selected HIV+ patients and support the need for a larger controlled trial to establish which HIV+ patients might be expected to benefit from this therapy.