CASE CONTROL ETIOLOGIC STUDY OF SARCOIDOSIS

美国的10个临床中心正在为NIH赞助的一项名为“结节病的病例对照病因学研究”的研究招募病例。目标包括：1)测试与环境、职业、生活方式和其他结节病风险因素有关的假说；2)检查结节病的家族聚集性；3)测试关于结节病聚集的遗传假说；4)描述结节病的自然历史，特别是在非裔美国人等似乎受到不成比例影响的群体中；5)确定进展到更严重疾病的风险因素；以及6(实施一个系统来存储来自病例和对照对象的血细胞、血浆和血清以及代表从轻微到严重疾病的一系列典型结节病病例的支气管肺泡灌洗液和细胞)。

Ten clinical centers in the United States are recruiting cases for an NIH sponsored study titled "A Case Control Etiologic Study of Sarcoidosis." The objectives include: 1) to test hypotheses concerning environmental, occupational, lifestyle, and other risk factors for sarcoidosis, 2) examine the familial aggregation of sarcoidosis, 3) To test genetic hypotheses concerning aggregation of sarcoidosis, 4) To describe the natural history of sarcoidosis, particularly among groups such as African-Americans who appear to be disproportionately affected, 5) To identify risk factors for progression to more sever disease and 6( To implement a system for storing biological specimens including blood cells, plasma, and serum from cases and control subjects and bronchoalveolar lavage fluid and cells from a well characterized series of cases of sarcoidosis which represent the spectrum from mild to severe disease.