ADOLESCENT COAS--A TWIN FAMILY DESIGN

申请人摘要：本提案的目的是研究 父亲酗酒对男性和女性的结果和功能的影响 青春期的后代 这一目标将通过比较以下数据来实现： 878对双胞胎的青春期后代，这些双胞胎要么是一致的，要么是不一致的 因为酗酒 双胞胎家庭研究提供了重要的设计优势： 同卵双胞胎共享所有基因，异卵双胞胎共享一半基因， 登记了对酒精中毒发作的遗传贡献。 第一 目的将决定是否以及在多大程度上酗酒的后代 双胞胎与非酒精性双胞胎的后代相比，在以下方面有所不同; 酒精使用和滥用，精神病理学，学业成绩，一般 心理社会能力和家庭关系的结构化评估 访谈和问卷调查。 第二，研究将扩展到 通过收集生物学母亲的酒精信息进行双家庭设计 使用和相关的母亲和父亲的精神病理学。 这将澄清 比较功能和结果数据之间的差异， 酗酒父亲的后代和非酗酒父亲的后代， 研究配偶/母亲效应和双胞胎父亲的作用 精神病理学与酗酒并存 母体效应可能是 控制，并分析将进行评估的作用， 强迫性交配，酗酒的父母结婚的倾向。 第三，为了了解父亲酗酒可能导致 影响后代，家庭传播的三种中介模式， 酒精中毒将被测试：异常社会化，负面影响 监管和药理脆弱性。 这项研究使 使用一种独特的资源，因为双胞胎父亲都是家庭成员。 越南时代双胞胎登记处，并都参加了前几波的 数据收集。 当这些父亲的后代还在 青少年、宝贵的诊断、人口统计和行为数据， 使我们能够描述独立变量，例如父亲的饮酒情况， 病史、精神病理学和人口统计学变量，如收入和 教育和家庭组成。 因此，建议的研究成果 作为第二波调查的优点是， 信息家庭已经确定。

APPLICANT'S ABSTRACT: The objective of this proposal is to study the impact of paternal alcoholism on outcomes and functioning of male and female adolescent offspring. This aim will be accomplished by comparing data on adolescent offspring of 878 twins who are either concordant or discordant for alcoholism. Twin family studies afford important design advantages: identical twins share all their genes and fraternal twins share half so that genetic contributions to the onset of alcoholism are enrolled. The first aim will determine whether and to what extent the offspring of alcoholic twins compared to the offspring of non-alcoholic twins differ in regard to; alcohol use and abuse, psychopathology, academic achievement, general psyhcosocial competence and family relationships assessed by structured interviews and questionnaires. Second, the study will be extended to a twin-family design by collecting information on biological mothers' alcohol use and relevant maternal and paternal psychopathology. This will clarify differences between the comparative functioning and outcome data for the offspring of alcoholic fathers and offspring of non-alcoholic fathers by examining the role of spousal/maternal effects and twin father psychopathology co-morbid with alcoholism. Maternal effects can be controlled, and analysees will be conducted to assess the role of assortative mating, the tendancy of alcoholic parents to marry each other. Third, in order to understand the mechanisms whereby paternal alcoholism may impact offspring, three mediation models for familial transmission of alcoholism will be tested: deviant socialization, negative affect regulation and pharmacological vulnerability. This proposed research makes use of a unique resource because the twin fathers are all members of the Vietnam Era Twin Registry and have all participated in previous waves of data collection. While the offspring of these fathers are still adolescents, invaluable diagnostic, demogrphic and behavioral data have allowed us to characterize independent variables such as fathers' drinking history, psychopathology, and demographic variables such as income and education and family composition. Therefore, the proposed research gains the advantage of being a second wave investigation in which maximally informative families have already been ascertained.