TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICS

这是一份申请，请求支持继续1994年启动的一项培训计划，该计划致力于对以下人员进行严格培训：(1)在风湿病学或骨科学科完成临床培训的上进心强的医生；(2)在骨科培训期间选择获得博士学位的医生；(3)新近毕业的博士S致力于开展风湿病或骨科疾病的研究；以及(4)进入新批准的内科-专科研究途径的内科住院医生。该计划提供密切监督的密集实验室经验，强调应用最先进的分子生物学、遗传学、细胞生物学和生物化学方法来研究影响结缔组织和肌肉骨骼系统的疾病的病因和发病机制。这一培训计划的主要优势是：(1)对影响到很大一部分人口的具有重大公共卫生和社会经济重要性的疾病的研究采取全面和多学科的方法；(2)从最近招募到托马斯·杰斐逊大学的众多成员中挑选出一批高生产率和有成就的研究人员；(3)教员的专业知识和研究兴趣的多样性，以及他们应用最先进的分子生物学方法来研究各种风湿和肌肉骨骼疾病；以及(4)教师长期致力于内科科学家和博士S的培训。我们建立的项目代表着将我们机构以前正在进行的各种培训活动整合为一个统一的项目，该项目高度专注于风湿和肌肉骨骼疾病的病因和发病机制研究。提供的培训机会有一个统一的目标，即使受训者准备好将最先进的分子生物学、遗传学、细胞生物学和生物化学方法应用于研究影响肌肉骨骼系统的各种疾病。培训活动包括直接监督的实验室研究，辅以正式的课程工作，出席大量预定的讲座和研讨会，出席并介绍期刊俱乐部，以及在机构和国家会议上介绍研究成果。项目完成后，学员将为获得学术任命和从事内科科学家或博士的职业生涯做好非常充分的准备。S能够在风湿学和骨科相关领域建立独立的研究项目。

This is an application requesting support to continue a Training Program initiated in 1994 devoted to the rigorous training of: (1) highly motivated physicians who have completed their clinical training in the disciplines of Rheumatology or Orthopedics; (2) physicians who have chosen to obtain a Ph.D. degree during their training in Orthopedics; (3) recently graduated Ph.D.'s committed to conduct research applicable to Rheumatology or Orthopedic diseases; and (4) Internal Medicine Residents entering the newly approved Internal Medicine-Subspecialty Research pathway. The program provides closely supervised intensive laboratory experience emphasizing the application of state of the art methods of Molecular Biology, Genetics, Cell Biology and Biochemistry towards the investigation of the etiology and pathogenesis of diseases affecting the connective tissues and the musculoskeletal system. The major strengths of this Training Program are: (1) the comprehensive and multi-disciplinary approach to the study of disorders of great public health and socioeconomic importance which affect a large segment of the population; (2) the cadre of highly productive and accomplished investigators that have been selected from the numerous members recruited in the recent past to Thomas Jefferson University; (3) the diverse nature of the expertise and research interests of the faculty and their application of the most advanced molecular biological approaches to the study of various rheumatic and musculoskeletal diseases; and (4) the long-term commitment of the faculty to the training of Physician Scientists and Ph.D.'s. The program we established represents a consolidation of various training activities previously ongoing at our institution into a unified program which is highly focused on the study of the etiology and pathogenesis of rheumatic and musculoskeletal diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of Molecular Biology, Genetics, Cell Biology and Biochemistry to the study of a broad spectrum of diseases affecting the musculoskeletal system. The training activities consist of directly supervised laboratory research supplemented by formal course work, attendance to a large number of scheduled lectures and seminars, attendance to and presentation of journal clubs, and presentation of research results at institutional and national meetings. At the completion of the program, the trainees will be extremely well prepared to obtain academic appointments and to pursue careers as Physician- Scientists or as Ph.D.'s capable of establishing independent research programs in areas relevant to Rheumatology and Orthopedics.