Cognitive and Pharmacotherapy for Suicidal Adolescents

描述(由申请人提供)：此职业发展申请表 该奖项描述了临床试验领域的培训和研究计划。 在儿童和青少年中，并将使候选人能够追求 检验两种不同药物组合的有效性的研究计划 治疗抑郁、有自杀倾向的青少年。这样做的主要目标是 发展奖是给候选人作为独立人士获得专业知识的奖项 精神病学临床试验的调查员，特别是儿童和 青少年。本次发展奖的现场指导将由 David Goldston博士(主要导师)和Curt Furberg博士(临床导师 试验方法)。该发展奖的外部导师包括Dr。 约翰·马奇和约翰·库里(杜克大学医学中心)。外部 该发展奖的顾问包括David Brent博士、Maria Kovacs博士、 格雷厄姆·埃姆斯利和托马斯·埃利斯。本文件中描述的研究研究 应用程序旨在检验两种方法的可行性和有效性 不同的治疗组合(认知-行为联合治疗和 药物疗法与支持疗法和教育相结合的对比 药物疗法)用于抑郁、有自杀倾向的青少年。一个小规模的随机 对照试验将被用来检验组合的假说 认知行为疗法和药物疗法将比 支持疗法教育与药物疗法相结合在减少性疾病中的应用 青少年的抑郁症状和自杀行为(包括自杀 构思)。

DESCRIPTION (provided by applicant): This application for a career development award describes a plan for training and research in the area of clinical trials among children and adolescents, and will allow the candidate to pursue a program of research examining the efficacy of two different combinations of treatments for depressed, suicidal adolescents. The primary objective of this development award is for the candidate to gain expertise as an independent investigator in psychiatric clinical trials, particularly with children and adolescents. On-site mentoring for this development award will be provided by Dr. David Goldston (primary mentor) and by Dr. Curt Furberg (mentor in clinical trials methodology). External mentors for this development award include Drs. John March and John Curry (Duke University Medical Center). External consultants for this development award include Drs. David Brent, Maria Kovacs, Graham Emslie and Thomas Ellis. The research study described in this application is designed to examine the feasibility and efficacy of two different combinations of treatment (combined cognitive-behavioral therapy and pharmacotherapy vs. combined supportive therapy and education and pharmacotherapy) for depressed, suicidal adolescents. A small randomized contolled trial will be used to test the hypothesis that combined cognitive-behavioral therapy and pharmacotherapy will be more efficacious than combined supportive therapy education and pharmacotherapy in decreasing adolescents' depressive symptoms and suicidal behaviors (including suicidal ideation).