NEUROBIOLOGIC SUBSTRATES OF STUTTERING

描述：候选人提出了五年的支持期，以允许 H发展她的研究技能，这样她就可以成为一个独立的 能够利用尖端技术进行研究的科学家 MRI数据的量化分析。在这项提案中，她将使用这些 研究口吃的神经生物学基础的技术，但她 建议最终可以使用测试技术来解决各种 临床人群中的脑-行为关系。的具体方面 值得注意的建议包括： 研究的主要焦点一直是试图定义解剖学 基础认知和其他大脑功能通过量化的方法 M图像分析。她在同行评议的期刊上列出了8篇论文，3篇 目前正在印刷的手稿和正在审查的4份手稿。她是第一个 6 o已出版/正在出版的手稿的作者。 研究计划(从PI的具体目标修改而来)：主要目标 这个项目是研究口吃的神经解剖学模型。要实现这些目标 目标PI建议进行四个实验，以调查 口吃者和非口吃者的关系行为不对称性。 实验1将考察语音产生与语言生成的关系 坐骨神经前部言语语言区的不对称性 三角肌(盖部)。实验2将调查 后脑言语知觉不对称性的关系 语音语言区域(临时平面)。实验3将调查 运动灵巧性与大脑皮质和大脑皮质不对称性的关系 皮质下运动区(中央卵丘、褶球)。实验 1、2和3将被限制为一致的右撇子。作为手的偏好 可能是一个重要的自变量，左撇子口吃和左撇子 在实验4中，手部非口吃者将使用相同的 实验1、实验2和实验3中要采用的措施。 这个项目将关注口吃者的大脑优势。少校 这项研究的假设是，口吃的人有解剖学和 支配地位的行为异常。

DESCRIPTION: The candidate proposes a five year period of support to permit h to develop her research skills so that she may become an independent research scientist capable of utilizing sophisticated techniques to perform quantitativ analyses of MRI data. In this proposal she will employ these techniques to investigate the neurobiologic substrate of stuttering, but she suggests that t techniques may ultimately be used to address a variety of brain-behavior relations in clinical populations. Specific aspects of the proposal which warrant attention include the following: The major focus of research has been the attempt to define the anatomic basis cognitive and other brain functions by means of the quantitative analysis of M images. She lists 8 publications in peer-reviewed journals, 3 manuscripts currently In Press and 4 manuscripts under review. She is first author of 6 o the published/in press manuscripts. Research Program (modified from the PI's Specific Aims): The major goal of th project is to study neuroanatomic models of stuttering. To achieve these goal the PI proposes to conduct four experiments that investigate the relationship behavioral asymmetries in people who stutter and nonstutterers. Experiment 1 will investigate the relationship of speech production to asymmetries in anterior perisylvian speech-language regions (pars triangularis pars opercularis). Experiment 2 will investigate the relationship between speech perception asymmetries in posterior speech-language regions (planum temporale). Experiment 3 will investigate the relationship between motor dexterity and asymmetries in cortical and subcortical motor regions (central suclus, globus plallidus). Experiments 1, 2, and 3 will be limited to consistent right handers. As hand preference may be an important independent variable, left handed stutterers and left handed nonstutterers will be investigated in Experiment 4 using the same measures to be employed in Experiments 1, 2, and 3. This project will focus on cerebral dominance in stutterers. The major postulate of the study is that people who stutter have anatomic and behavioral anomalies of dominance.