STATISTICAL ANALYSIS OF GENETIC EVENTS IN TUMORIGENESIS

肿瘤抑制基因的定位和特征 对癌症的预防和治疗有着深远的影响。这个 这项研究的主要目标是开发统计工具来 加快寻找抑癌基因候选基因。具体的 这项研究的目的是：开发统计显著性检验 这将有助于确定肿瘤抑制基因候选基因的丢失 杂合性研究和缺失作图研究；提供方法 用于确定来自不同群体的等位基因丢失模式 患者有很大的不同；生产可公开使用的 用于实施这些程序的软件；并从生物学角度进行评估 肿瘤中等位基因丢失过程的重要特征 进步。 实现这些目标的方法将涉及制定 肿瘤发生中的遗传事件模型，主要集中在 等位基因丢失事件。将进行电力研究，以使 科学家确定样本量以实现不同水平的 确定肿瘤抑制基因候选。

The localization and characterization of tumor suppressor genes has profound implications for prevention and treatment of cancer. The primary goal of this research is to develop statistical tools to expedite the search for tumor suppressor gene candidates. The specific aims of this research are: to develop statistical significance tests that will help identify tumor suppressor gene candidates from loss of heterozygosity studies and deletion mapping studies; to provide methods for determining whether allelic loss patterns from different groups of patients are significantly different; to produce publicly available software for implementing these procedures; and to estimate biologically important characteristics of the allelic loss process in neoplastic progression. The methods for achieving these aims will involve the formulation of models for genetic events in tumorigenesis, focusing primarily on allelic loss events. Power studies will be performed which will allow scientists to determine the sample sizes to achieve various levels of certainty in the identification of tumor suppressor gene candidates.