BIOLOGICAL BASES OF DRUG SEEKING BEHAVIOR

描述：（申请人提供） 该计划为前和博士后培训支持的培训 能够进行临床前研究的专家， 从分子到行为， 发展、维持和消除药物寻求行为。三十一 俄勒冈州健康科学大学的研究生教师担任 作为博士后研究员和博士的导师。学生 进入行为神经科学的基础科学研究生课程， 神经科学、生理学和药理学或细胞生物学。主要研究 区域代表三个层次。一些教师主要工作在 细胞/分子水平，使用分子生物学，电生理学， 电子显微镜技术。其他教师主要在以下级别工作： 生理学、生物化学和药理学系统，使用受体结合， 放射自显影、体内微透析和伏安法，以及电生理学 技术.最后，其他教师主要从事行为学方面的工作。 药理学，认知神经科学和药物遗传学，使用行为 测试，静脉药物自我管理，定量遗传学和 基因图谱以及计算机建模技术。广泛的领域 现有的教师合作包括：多巴胺能系统的研究， 从分子生物学到行为学;广泛的遗传学研究 药物反应的决定因素，从分子水平到统计水平 基因定位;以及对反应的习得和非习得决定因素的研究 药物，特别是其奖励作用和药物自我管理。 所有主要的敏感性、耐受性和依赖性/戒断现象 正在积极调查包括酒精在内的各类滥用药物。 培训包括基础科学的坚实课程基础，具体 滥用药物的药理学培训，以及广泛和持续的 参与研究。

DESCRIPTION: (provided by applicant) This program for pre- and postdoctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the behavioral on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Thirty-one members of the graduate faculty of the Oregon Health Sciences University serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or cell biology. Major research areas represent three levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, electrophysiological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and elecrophysiological techniques. Finally, other faculty work primarily in behavioral pharmacology,cognitive neuroscience, and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modelling techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self-administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse including alcohol are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research.