Human Perinatal Brain Injury and Outcome: MRI Assessemnt

描述(由申请人提供)：建议的研究综合了 应聘者在儿科神经放射学和物理学以及当地的背景 擅长急性脑损伤的磁共振成像，脑结构的磁共振分析 和新生儿大脑生理学。我们的目标是积累候选人的专业知识 最新的神经成像技术和她对新生儿的了解 生理学，以便更好地研究MR可观察物和 新生儿脑损伤。候选人处于完美的环境中，可以扩展 从成人人群到新生儿人群所使用的磁共振成像工具。 拟议的5年研究培训计划包括1)新生儿 神经生理学，2)扩散、灌流、光谱的理论和实践 和结构磁共振图像分析，3)临床研究设计，实验 统计学和伦理学。研究目标是开发磁共振技术， 预测急性期颅脑损伤的严重程度并定量 在2岁时评估结构结果。我们假设这些区域 在急性期发现的表观弥散降低(ADC)可以是 与不同的生理环境相关的，由 灌注加权成像和质子光谱分析。我们还假设 这些在生命最初几天观察到的生理变量预测了 2岁时原发和继发性脑损伤的严重程度。这个 项目预计只会帮助候选人建立一个独立的 研究生涯，并有助于了解围产期大脑 受伤。

DESCRIPTION (provided by applicant): The proposed study combines the candidate's background in pediatric neuroradiology and physics as well as local expertise in MR imaging of acute brain injury, MR analysis of brain structure and neonatal brain physiology. The goal is to build the candidate's expertise in stateoftheart neuroimaging techniques and her knowledge of neonatal physiology in order to better study the links between MR observables and neonatal brain injury. The candidate is in the perfect environment to extend the MR imaging tools used in the adult population to the neonatal population. The proposed 5year research training Program consists of 1) neonatal neurophysiology, 2) theories and practice of diffusion, perfusion, spectroscopy and structural MR image analysis, and 3) clinical research design, experimental statistics and ethics. The research goal is to develop MR techniques that predict the severity of brain injury in the acute period and to quantitatively assess the structural outcome at 2 years of age. We hypothesize that regions of decreased apparent diffusion (ADC) identified in the acute time period can be associated with different physiological environments, as determined by perfusion weighted imaging and proton spectroscopy. We also hypothesize that these observed physiological variables in the first days of life predict the severity of both the primary and secondary brain injury at 2 years of age. The project is expected to only help the candidate establish an independent research career and to contribute to an understanding of perinatal brain injury.