Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHD
探索成人先心病患者高级多模态脑 MRI 表型、基因和认知结果之间的关系
基本信息
- 批准号:10371086
- 负责人:
- 金额:$ 78.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAllelesApolipoprotein EBirthBostonBrainCardiacCardiovascular systemCaringChildCognitiveComplexDataDevelopmentDiffusionElderlyEquilibriumExecutive DysfunctionFunctional Magnetic Resonance ImagingFutureGenesGenotypeGoalsHematocrit procedureHypoxiaImage AnalysisImpairmentIndependent LivingIndividualInterventionKnowledgeLifeLive BirthMagnetic Resonance ImagingMeasuresMedicalMental HealthMethodsNeurocognitiveNeurodevelopmental DisabilityNeuropsychologyOperative Surgical ProceduresOrganizational ChangeOutcomePathway interactionsPatientsPatternPeripheralPhenotypeRestRiskRoleServicesTestingTherapeutic InterventionTimeUnited StatesVariantbrain magnetic resonance imagingcohortcongenital heart disorderd-transposition of the great arteriesdisabilityexecutive functiongenetic testinggenetic varianthigh riskimprovedimproved outcomein uteroinfancymultimodalitynoveloperationpostnatalprenatalprenatal therapyresilienceresponse
项目摘要
Congenital heart disease (CHD) affects ~1% of all live births in the United States. Over 85% of individuals with
CHD now live well into adulthood1–4, exposing a burden of non-cardiac disabilities, such as neurodevelopmental
disabilities. In fact, over half of all children with moderate or complex CHD suffer from neuropsychological deficits,
with impaired executive functions (EF) the most common. EF are critical higher-order neurocognitive functions
important for independent living and mental health. However, predicting who will be more impaired and in need
of intervention is challenging, as routinely measured patient and medical factors explain only one-third of the
variance in outcomes. Because impaired EF is particularly amenable to treatment, better predictors of EF are
needed to appropriately allocate services and improve outcomes. To develop such methods, we first focus on
dextro-transposition of the great arteries (d-TGA). Among the severe forms of CHD, d-TGA is the more common,
occurring in 3/10,000 live births. d-TGA leads to severe in utero hypoxia that is corrected soon after birth with
an arterial switch operation. Additional surgery and cardiovascular sequelae are rare. Thus d-TGA patients have
the most uniform postnatal course of all CHDs but, like other CHDs, is associated with hypoxia and has significant
yet variable impairment in EF. This project leverages adult d-TGA subjects being studied under R01HL135061
and d-TGA patients involved in prior Boston trials to create the largest, best characterized d-TGA cohort to date.
We propose to perform sophisticated image analysis on brain MRI data and add genetic testing focused on
neuroresilience and hypoxia response genes. First, we will employ our sulcal pattern analysis to determine the
extent of in utero alterations in brain development, as sulcal patterns are determined prenatally and remain stable
into adult life. Second, we will explore the rich club structural and functional networks to separate highly
connected central hubs (rich club) that form early in life from less connected peripheral regions which are thought
to be adaptive. The overarching goal of this study is to use novel MRI analyses to determine the brain
organizational changes associated with altered EF and the modulating role of neuroresilience and hypoxia
response genes in adults with d-TGA. Toward these ends, we propose the following specific aims: Aim 1.
Determine the relationship between sulcal patterns and executive function in adults with d-TGA and if this
relationship is modified by (a) presence of neuro-resilience gene ApoE ε2 or ε4 alleles, or (b) variants in hypoxia
response genes. Aim 2/3. Determine the relationship between structural/functional connectivity using rich club
and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuro-resilience
gene ApoE ε2 or ε4 alleles or (b) variants in hypoxia response genes. Successful completion would help
determine brain changes associated with altered EF and the potential modulating role of neuroresilience and
hypoxia response genes as well as inform the balance of in utero versus adaptive changes. This knowledge is
relevant to the larger CHD group and will inform the need for prenatal versus postnatal interventions.
先天性心脏病(CHD)影响了美国约1%的活产婴儿。超过85%的人有
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Patricia Ellen Grant其他文献
Design and rationale of “Antecedents and correlates of well-being in young adults with congenital heart disease in the Boston Circulatory Arrest Study (BCAS-adult)”
“波士顿循环骤停研究(BCAS-成人)中先天性心脏病青年成人幸福感的前因和相关因素”的设计与原理
- DOI:
10.1016/j.ahj.2025.05.012 - 发表时间:
2025-11-01 - 期刊:
- 影响因子:3.500
- 作者:
Michelle Gurvitz;Alexandra Roseman;Lori Sahakian;Johanna Calderon;Ai Wern Chung;Donna Duva;Borjan Gagoski;Clare Hobson;Jee Won Kang;Adrienne Kovacs;Patricia Ibeziako;Michael Rivkin;David Bellinger;David Wypij;Patricia Ellen Grant;Jane W. Newburger - 通讯作者:
Jane W. Newburger
Patricia Ellen Grant的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Patricia Ellen Grant', 18)}}的其他基金
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)
新生儿脑病 MRI 生物标志物联盟 (COMBINE)
- 批准号:
10436592 - 财政年份:2022
- 资助金额:
$ 78.37万 - 项目类别:
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)
新生儿脑病 MRI 生物标志物联盟 (COMBINE)
- 批准号:
10614588 - 财政年份:2022
- 资助金额:
$ 78.37万 - 项目类别:
Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHD
探索成人先心病患者高级多模态脑 MRI 表型、基因和认知结果之间的关系
- 批准号:
10579297 - 财政年份:2021
- 资助金额:
$ 78.37万 - 项目类别:
Neonatal Hypoxic Ischemic Encephalopathy: Potential of Innovative NIRS to Optimize Hypothermia
新生儿缺氧缺血性脑病:创新 NIRS 优化低温的潜力
- 批准号:
10632024 - 财政年份:2014
- 资助金额:
$ 78.37万 - 项目类别:
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
围产期脑损伤:创新 NIRS 优化低温治疗的潜力
- 批准号:
8853307 - 财政年份:2014
- 资助金额:
$ 78.37万 - 项目类别:
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
围产期脑损伤:创新 NIRS 优化低温治疗的潜力
- 批准号:
9093827 - 财政年份:2014
- 资助金额:
$ 78.37万 - 项目类别:
Neonatal Hypoxic Ischemic Encephalopathy: Potential of Innovative NIRS to Optimize Hypothermia
新生儿缺氧缺血性脑病:创新 NIRS 优化低温的潜力
- 批准号:
10446683 - 财政年份:2014
- 资助金额:
$ 78.37万 - 项目类别:
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
围产期脑损伤:创新 NIRS 优化低温治疗的潜力
- 批准号:
8639152 - 财政年份:2014
- 资助金额:
$ 78.37万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 78.37万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 78.37万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 78.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 78.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 78.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)