Development of data packages for registration of novel nematicides based on essential oil formulations

项目合作伙伴Barrier Biotech Ltd(BB)、Syngenta Ltd(SYN)和John Innes Centre(JIC)正在申请资金，以开发基于精油配方的新型杀线虫产品。这些配方将针对影响可耕种根茎作物的线虫，并取代由于《植物保护产品指令》(91/414/EEC)的变化而退出市场的现有商业杀线虫剂。BB在植物油方面拥有广泛的商业经验，初步证据表明，他们的专利配方可以控制农业和园艺作物中的线虫问题。天然配方在低浓度下提供药效；对环境的风险最小；将增强用户的安全性，并可能由于化学成分的复杂性和自然发生的变异性而提供更持久的虫害防治。该项目旨在为新型杀线虫制剂的CRD和/或DG SANCO注册编制档案。这些档案将成为开发适销对路的商业产品的基础，旨在减少产量损失，减少供应链中的浪费和成本，并在英国农业领域推广具有成本效益和安全的解决方案。值得注意的是，土豆胞囊线虫每年仅给英国土豆产业造成的损失就约为4300万英镑。据估计，全球每年由线虫造成的损失高达800-1250亿美元。在价值10亿美元的全球杀线虫剂市场上，新配方可能会取代现有非熏蒸产品的20%-30%。这些配方可能对甜菜、西红柿和黄瓜等其他主要农作物上的线虫有效，需要单独提供资金。

Project partners Barrier Biotech Ltd (BB), Syngenta Ltd (SYN) and the John Innes Centre (JIC) are applying for funding to develop novel nematocide products based on essential oil formulations. These formulations will target nematodes affecting arable root crops and substitute existing commercial nematicides coming off the market due to changes in the Plant Protection Products Directive (91/414/EEC). BB has extensive commercial experience with plant oils and has preliminary evidence suggesting that their patented formulations can control nematode problems within both agricultural and horticultural crops. Natural formulations provide efficacy at low concentrations; represent a minimal risk for the environment; will enhance user safety and are likely to provide more durable pest control due to the complexity of chemical composition and naturally occurring variability. The project aims to develop dossiers for CRD and/or DG SANCO registration of novel nematicide formulations. These dossiers will be the foundation of the development of marketable commercial products designed to cut losses in yield, reduce wastage and costs within the supply chain and promote cost effective and secure solutions within UK agriculture. Notably, potato cyst nematode costs the UK potato industry alone an estimated 43m/year. Damage caused by nematodes worldwide is estimated annually at $80-$125 bn. New formulations could replace 20-30% of the existing non-fumigant products on the $1 billion global nematicide market. These formulations are likely to be effective against nematodes on other major agricultural crops such as sugar beet, tomato and cucumber for which separate funding will be required.