TRANSGENIC ANALYSIS OF LH HYPERSECRETION

描述：(改编自《调查者摘要》)：本基金中的研究 周期将集中在假设慢性高分泌的黄体生成素，与一个 FSH的重大贡献，通过改变导致肿瘤形成 表达一个复杂的基因网络，包括一个进行性的 促黄体生成素受体下调，细胞周期蛋白D2增加。这个 研究人员还将绘制和克隆该基因中的三个非等位变异 胃癌发生所必需的cf-1基因组及其对其完整的贡献 洞察力。在鉴定独一无二的基因表达谱中 颗粒细胞瘤，这些研究应该有助于更好地 对肿瘤形成的许可和致因事件的理解。

DESCRIPTION: (Adapted from the Investigator's Abstract): Studies in this grant period will focus on the hypothesis that chronic hypersecretion of LH, with a significant contribution from FSH, causes tumor formation by altering expression of a complex network of genes including a progressive down-regulation of the LH receptors and an increase in cyclin D2. The investigators will also map and clone the three non-allelic variants in the CF-1 genome necessary for GC tumorigenesis and contribute to its complete penetrance. In identifying gene expression profiles unique to the formation of granulosa cell tumors, these studies should contribute to a better understanding of permissive and causative events that underlie tumor formation.