Duty ratio: a simple method for quantifying loop gain during breathing instability

提出了一种计算睡眠呼吸障碍患者严重程度的新方法。该提案还在动物和人类实验中验证了我们的方法的有效性。该方法不需要对患者进行干预，为检测治疗心力衰竭患者呼吸不稳定模式的疗效提供了一种手段，这些患者呼吸不稳定与预后不良有关。

This proposal presents a new method for calculating the severity of sleep disordered breathing in patients. The proposal also tests the effectiveness of our method in experiments in animals and humans. The method, which requires no intervention in the patient, offers promise as a means for testing the efficacy of treatments for the unstable breathing pattern found in patients with heart failure in whom the presence of unstable breathing is associated with poor outcome.