The SNORE-ASA study: a Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea

睡眠呼吸暂停在老年人中很常见，但不确定它是否会导致智力下降，就像中年人一样。除了疲劳，睡眠呼吸暂停还会影响大脑血液供应，从而导致智力下降。这可能是阿司匹林可以预防的。我们将对3000名健康的老年人进行为期4年的睡眠呼吸暂停测试。一半的人将服用阿司匹林。我们预测，睡眠呼吸暂停患者的智力会下降得更快，而阿司匹林将部分逆转这一趋势。

Sleep apnoea is very common in the elderly, but it is uncertain whether it leads to a decline in mental abilities as it can in the middle-aged. Apart from fatigue, sleep apnoea also causes mental decline by affecting brain blood supply. This may be preventable with aspirin. We will track 3,000 healthy elderly for 4 years, after testing for sleep apnoea. Half will take aspirin. We predict that mental ability will decline faster with sleep apnoea, and that aspirin will partly reverse this.