INTERACTIVE 4D VISUALIZATION OF CONGENITAL HEART DISEASE

描述（摘自申请摘要）：开发和临床 心血管系统软件显示技术新系列的测试 提出了磁共振成像（MRI）数据。 这些努力 预计将加强诊断过程，并促进目前 对儿童的治疗和患者管理做出具有挑战性的决定 严重的先天性心脏病 特别是，发育不良的评估 左、右心综合征和单心室心脏需要改善 可视化和功能量化工具， 监测严重性和功能状态。 该系统的初步设计已基本完成。 设计特点 这些软件系统是基于最近广泛使用 三维渲染硬件和11年临床观察 第一年内研究中心的心脏MRI经验 一个临床上可用的原型可以交付测试 和用户反馈，包括高度流线型的图像数据管道， 先进的当代用户界面，以及其他重要功能， 广泛的临床评价。 提出的动态三维显示技术结合了最大的解剖 在多切片ECG触发的电影MRI扫描中可用的信息 通过以正确的3-D同时显示所有切片图像 动态的几何透视（节拍的循环电影 心）。 用户可以实时操纵所显示的切片对象， 改善局部解剖可视化，生成沿着的重新格式化视图 在飞行中切割平面，并为其他观察者注释显示， 突出显示感兴趣的3D区域。 拟议的工作包括：（1）开发第一个原型， 广泛的预先存在的内部开发的软件库，（2）临床 从项目第二年起对技术进行评估，（3） 实施增强功能，包括量化和显示 基本心脏功能参数，包括血液动力学数据， 跟进用户反馈，并添加有限的DICOM I/O功能。

DESCRIPTION (Taken from application abstract): Development and clinical testing of a new family of software display techniques for cardiovascular magnetic resonance imaging (MRI) data are proposed. These efforts are anticipated to enhance the diagnostic process and facilitate currently challenging decisions on therapy and patient management of children with severe congenital heart disease. In particular, assessment of hypoplastic left and right heart syndromes and univentricular heart require improved visualization and function quantification tools for evaluation and monitoring of severity and functional status. The initial design of the system is largely completed. Design features of the software system are footed on recent improvements in widely available 3-D rendering hardware and on observations made during 11 years of clinical experience with cardiac MRI at the investigation site During the first year of the project a clinically usable prototype can be delivered for testing and user feedback, including a highly streamlined image data pipeline, sophisticated contemporary user interface, and other features essential for extensive clinical evaluation. The proposed dynamic 3-D display technique combines a maximum of anatomical information available in a multi-slice ECG-triggered cine-MRI scan of the heart, by displaying all slice images simultaneously in correct 3-D geometric perspective in dynamic fashion (a cyclic movie of the beating heart). A user can manipulate in real-time the displayed slice objects to improve visualization of regional anatomy, generate reformatted views along cutting planes on-the-fly, and annotate the display for other observers by highlighting 3-D regions of interest. The proposed effort includes (1) development of first prototype using extensive preexisting in-house developed software libraries, (2) clinical evaluation of the technique from the second year of the project onwards, (3) implementation of enhancements including quantitation and display of essential cardiac function parameters including hemodynamic data and follow-up on user feedback, and adding limited DICOM I/O functionality.