Core--Ovarian cancer clinical network

描述：（申请人描述）在最基本的分子水平上了解卵巢癌的潜力对科学界提出了挑战，要求他们应用新的和正在发展的技术来推进我们对这种致命疾病的理解。目前缺乏的是对足够大的卵巢癌患者或有卵巢癌家族风险的女性进行前瞻性随访的机会，以明确解决这些问题。FCCC建议建立卵巢癌临床网络核心，这是一个以研究为基础的基础设施，以促进转化研究的开展，并将新的预防、筛查和治疗策略转化为临床实践。该中心代表了FCCC、Fox Chase网络、库珀医疗中心、天普大学、新泽西癌症研究所、好时医疗中心和宾夕法尼亚大学的合作伙伴关系，并提供了广泛的种族、社会经济和农村/城市人口的访问。在1600多个高风险乳腺癌家庭的基础设施基础上，利用核心设施的综合资源，将汇集具有一个或多个卵巢癌病例的组织病理学记录的家庭队列。将收集有关医疗、生殖、家庭和生活方式因素的广泛资料。将采集所有参与者的血液样本。将要求受影响的个体以及未受影响的家庭成员进行卵巢切除以进行预防。该核心将设计、开发和支持一个全面的信息管理系统，以确保准确的数据输入和维护，并满足SPORE调查人员的需求。咨询和筛查方案将标准化并分发给卫生保健专业人员。该设施将建立在Fox Chase正在进行的开创性工作的基础上，以满足高风险家庭的需求，并将扩大这些努力，以促进多学科研究项目。动态卵巢癌研究数据库的创建提供了一个独特的机会来解决多学科研究问题，并将基因革命产生的关于卵巢癌的知识带给社区。

DESCRIPTION: (Applicant's Description) The potential to understand ovarian cancer at the most basic molecular level poses a challenge to the scientific community to apply the new and developing technologies to advance our understanding of this deadly disease. What has been lacking is the opportunity to prospectively follow a sufficiently large cohort of women with ovarian cancer or with a familial risk for ovarian cancer to definitively address these questions. The FCCC proposes the establishment of The Ovarian Cancer Clinical Network Core, a research-based infrastructure to facilitate the conduct of translational research and to transfer novel prevention, screening and treatment strategies into clinical practice. This core represents a partnership of FCCC, the Fox Chase Network, Cooper Medical Center, Temple University, the Cancer Institute of new Jersey, Hershey Medical Center, and the University of Pennsylvania and provides access to a wide spectrum of ethnic, socioeconomic and rural/urban populations. Building upon an established infrastructure of over 1600 high risk breast cancer families and using the combined resources of the core facility, a cohort of families with histopathologic documentation of one or more cases of ovarian cancer will be assembled. Extensive information on medical, reproductive, family and lifestyle factors will be collected. Blood samples will be collected from all participants. Ovarian tissue specimens will be requested from affected individuals as well as those unaffected family members undergoing oophorectomy for prophylaxis. The core will design, develop, and support a comprehensive information management system to ensure accurate data entry and maintenance and to serve the needs of the SPORE investigators. Counseling and screening protocols will be standardized and disseminated to health care professionals. This facility will build upon the seminal work underway at Fox Chase to serve the needs of high-risk families and will expand these efforts to foster multidisciplinary research projects. The creation of a dynamic ovarian cancer research database provides a unique opportunity to address multidisciplinary research questions and to bring the knowledge about ovarian cancer generated by the genetic revolution to the community.